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Skin-melanocytic tumor
Nevi
Pigmented spindle cell nevus

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 14 April 2013, last major update February 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

General
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Terminology
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Epidemiology
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Sites
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Clinical features
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Case reports
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Treatment
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Dermoscopic description
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Clinical images
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Rim of brown globules around lesion

Pseudopods arranged regularly at periphery
and retiform depigmentation at center

Small multicolored lesion showing
irregular and ill-defined borders

Small slightly raised dark
lesion with defined borders

Small and symmetrical lesion differs from Spitz
nevus in its uniform dark blue-black pigmentation
that may suggest melanoma clinically (AFIP)
Micro description
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Micro images
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Various images

Symmetric pigmented tumors
AFIP images:

Fig A: bilaterally symmetrical lesion has proliferation of nested melanocytes that "rain down" from epidermis and expand papillary dermis without involving reticular dermis
Fig B: lesional cells mature from superficial to deep
Fig C: the most lateral cells are in the form of a nest rather than single cells (well circumscribed)

Some intraepidermal nests show clefts similar to Spitz nevi, but they more often blend imperceptibly with keratinocytes in a pigmented spindle cell nevus (fig B);
Mitotic figures in the epidermis are common, but they are not numerous in the dermis;
Maturation towards a small nevoid cell at the base in the papillary dermis, without involvement of the reticular dermis, is typical

Fig B: bilaterally symmetrical lesion whose cells mature from epidermis to base of papillary dermis, respecting the reticular dermis interface (fig B);
Fig C: nucleolated lesional cells with abundant, coarse and dusty pigment are characteristic
Symmetric pigmented tumor; #2; #3; #4

Pigmented spindle cell tumor


Positive stains
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Molecular description
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Videos
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Differential diagnosis
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End of Skin-melanocytic tumor > Nevi > Pigmented spindle cell nevus


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