Skin melanocytic tumor
Melanoma
Primary dermal melanoma


Topic Completed: 1 May 2013

Revised: 5 April 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Primary dermal melanoma
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Cite this page: Hale CS Primary dermal melanoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skintumormelanocyticprimarydermalmelanoma.html. Accessed May 24th, 2019.
Definition / general
  • Extremely rare
  • Melanoma subtype confined to dermis or subcutis
Epidemiology
Sites
  • No apparent site predilection
Clinical features
  • Solitary and well circumscribed but unencapsulated, deep dermal or subcutaneous melanoma
Case reports
Treatment
  • Prolonged survival (Arch Dermatol 2004;140:99) compared to melanoma of similar thickness but may recur or develop metastases
Dermoscopy
  • Lack of atypical pigmented network and radial streaks; papillomatous projections with light brown and dark brown blotchy areas (Am J Dermatopathol 2009;31:574)
Clinical images

Images hosted on other servers:

Blue nodule on arm

Slightly bluish scalp nodule

Microscopic (histologic) description
  • Melanoma confined to dermis or subcutis; mean Breslow depth is 1 cm
  • No in situ component, regression or ulceration
  • No associated nevus
Microscopic (histologic) images

Images hosted on other servers:

Various images

Metastatic melanoma versus primary dermal melanoma

Positive stains
Molecular / cytogenetics description
  • Strong expression of KIT (CD117) by immunohistochemistry but no EWS / ATF1 fusion transcript (J Dermatol 2009;36:346)
Differential diagnosis
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