Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Skin-melanocytic tumor
Nevi
Spitz nevus

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 20 April 2013, last major update February 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

See also atypical Spitz nevus, desmoplastic Spitz nevus

General
=========================================================================
Terminology
=========================================================================
Epidemiology
=========================================================================
Sites
=========================================================================
Clinical features
=========================================================================
Case reports
=========================================================================
Treatment
=========================================================================
Clinical images
=========================================================================

Small, symmetrical, pink-tan lesion

Various images

On ear of child

11 year old boy with dark pigmented arm lesion
Micro description
=========================================================================
Micro images
=========================================================================

Various images

Limited Ki-67 staining

Strong S100A6 staining

Various images

Spitz nevus-figures a-c

Compound Spitz tumor

Compound Spitz nevus

Lip lesion - superficial nests with
spread of cells in deeper areas

Cells demonstrate pleomorphism,
hyperchromatism and multinucleation
AFIP images:

Bilaterally symmetric lesion has uniform hyperkeratosis with hypergranulosis, fairly uniformly elongated rete ridges
and a proliferation of melanocytes in the epidermis that "rain down" through the papillary dermis into the reticular dermis
as attenuated spindle cells


Fig A: bilaterally symmetrical lesion
Fig B: has lateral cells arranged in nests
Fig C: indicating that the lesion is well circumscribed; "transepidermal elimination" does not indicate pagetoid spread
Fig D: dermal lesional cells show imperfect, but definite maturation with attenuated single cells at the base of the lesion

Melanocytes extend focally into epidermis, mostly as nests;
the maturation into the dermis, globoid bodies in epidermis
and characteristic cell type are attributes of Spitz nevus, not melanoma

Pink eosinophilic globoid Kamino
bodies are probably apoptotic cells

Fig A: giant cells are commonly seen in Spitz nevi
Fig B: as are the large intranuclear cytoplasmic invaginations
that may also be seen in melanomas

Fig A: mitotic figures, if not numerous and especially when entirely superficial, are not indicative of melanoma
Fig B: maturation from large epithelioid cells to small nevus cells, from superficial to deep, within a Spitz
nevus is an extremely important diagnostic feature, as is the permeation of reticular dermis by attenuated
single cells at the base
Comparison with melanoma:

Fig A-H: Spitz nevus
Fig I: compared to spitzoid melanoma
Contributed by Angel Fernandez-Flores, MD, PhD, Hospital El Bierzo and Clinica Ponferrada, Spain:

Various images
Symmetric circumscribed lesion; nests of tumor cells with Kamino bodies; #2;

Nests of spindle cells; nests of epithelioid cells; #2; multinucleated cells;

Junctional; intradermal; #2; compound; #2; trunk; #2


Positive stains
=========================================================================
Negative stains
=========================================================================
Molecular description
=========================================================================
Differential diagnosis
=========================================================================
End of Skin-melanocytic tumor > Nevi > Spitz nevus


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).