Skin - Nonmelanocytic tumors
Lymphoma and related disorders
Acute lymphoblastic lymphoma
Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 15 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.
● Most common cutaneous lymphoma in children; rare in adults
● Aggressive behavior
● Either B cell (CD19+, CD20+, CD79a+), T cell (surface CD3+) or non-B non-T (negative for B cell markers and CD3)
● T cell subtypes have best prognosis
● Non-B non-T include:
(a) CD7+ stem cell lymphoma (CD7+, CD4-, CD56-, CD33 variable)
(b) blastic NK lymphoma (CD56+, CD4-, CD33-, CD123-, CD7 variable)
(c) myeloid/NK precursor cell leukemia (CD56+, CD4-, CD7+, CD33+)
(d) Blastic plasmacytoid dendritic cell neoplasm (CD4+, CD56+, CD123+, CD7 variable, CD33-); frequent skin lesions, aggressive, poor prognosis (Am J Surg Pathol 2003;27:1366)
● Stem cell transplantation may improve survival
● 10 year old boy with precursor B cell lymphoblastic lymphoma with only cutaneous involvement (Acta Derm Venereol 2009;89:540)
● 78 year old man with B-LBL presenting as a single cutaneous lesion (Korean J Hematol 2011;46:283)
50×60 mm non-tender, non-itching, dark red tumor with smooth surface on abdomen
● J Cutan Pathol 1999;26:379,
Am J Clin Pathol 2004;122 Suppl:S3
End of Skin - Nonmelanocytic tumors > Lymphoma and related disorders > Acute lymphoblastic lymphoma
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at [email protected] with any questions (click here for other contact information).