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Skin - Nonmelanocytic tumors

Lymphoma and related disorders

Acute lymphoblastic lymphoma

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 15 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.


● Most common cutaneous lymphoma in children; rare in adults
● Aggressive behavior
● Either B cell (CD19+, CD20+, CD79a+), T cell (surface CD3+) or non-B non-T (negative for B cell markers and CD3)
● T cell subtypes have best prognosis
● Non-B non-T include:
    (a) CD7+ stem cell lymphoma (CD7+, CD4-, CD56-, CD33 variable)
    (b) blastic NK lymphoma (CD56+, CD4-, CD33-, CD123-, CD7 variable)
    (c) myeloid/NK precursor cell leukemia (CD56+, CD4-, CD7+, CD33+)
    (d) Blastic plasmacytoid dendritic cell neoplasm (CD4+, CD56+, CD123+, CD7 variable, CD33-); frequent skin lesions, aggressive, poor prognosis (Am J Surg Pathol 2003;27:1366)
● Stem cell transplantation may improve survival

Case reports

● 10 year old boy with precursor B cell lymphoblastic lymphoma with only cutaneous involvement (Acta Derm Venereol 2009;89:540)
● 78 year old man with B-LBL presenting as a single cutaneous lesion (Korean J Hematol 2011;46:283)

Clinical images

5060 mm non-tender, non-itching, dark red tumor with smooth surface on abdomen

Micro images

Various images

Additional references

J Cutan Pathol 1999;26:379, Am J Clin Pathol 2004;122 Suppl:S3

End of Skin - Nonmelanocytic tumors > Lymphoma and related disorders > Acute lymphoblastic lymphoma

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