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Skin - Nonmelanocytic tumors

Carcinoma (non-adnexal)

Lymphoepithelioma-like carcinoma


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 15 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● May represent a primitive adnexal tumor
● Facial or neck nodule
● Female = male, older individuals
● Histologically similar tumors in genitourinary and other organ systems

Case reports
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● 85 year old man with 5 cm mass on forehead (Dermatol Online J 2012;18:7)
● 89 year old woman with cheek lesion (Dermatol Online J 2008;14:12)

Clnical images
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Forehead lesion

Gross description
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● Firm plaque

Micro description
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● Resembles upper respiratory tract tumor, with nests of high grade tumor cells in a syncytium, with a marked lymphocytic infiltrate
● Also has features of sweat gland, follicular or apocrine differentiation

Micro images
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Various images

Negative stains
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● EBV

Differential diagnosis
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● Squamous cell carcinoma
● Melanoma
● Other

End of Skin - Nonmelanocytic tumors > Carcinoma (non-adnexal) > Lymphoepithelioma-like carcinoma


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