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Skin - Nonmelanocytic tumors

Other tumors of skin


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 14 September 2012, last major update September 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.


● Malignant smooth muscle tumor similar to counterparts elsewhere
● Typically larger than leiomyomas with vascular invasion
● Recurs, but only rarely metastasizes
● May be associated with HIV infection

Case reports

● 59 year old woman with painless skin nodule (J Med Case Reports 2007;1:180)
● 67 year old woman with neck lesion (Cases J 2010;3:52)

Micro description

● Cellular lesions of smooth muscle type cells with atypia, necrosis and mitotic activity
● May have prominent vascular pattern, clear cell features, desmoplasia

Micro images

Various images

Positive stains

● HHF35 (90%), alpha-smooth muscle actin (90%), vimentin, desmin (75%) (Cancer 2009;115:4186)

Differential diagnosis

● Atypical fibroxanthoma (AFX)/malignant fibrous histiocytoma (MFH)
● Melanoma
● Kaposi sarcoma
● Spindle cell carcinoma
● Epithelioid angiosarcoma
● Malignant peripheral nerve sheath tumor

End of Skin - Nonmelanocytic tumors > Other tumors of skin > Leiomyosarcoma

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