Skin nonmelanocytic tumor
Other tumors of skin

Topic Completed: 1 September 2012

Minor changes: 14 October 2020

Copyright: 2001-2020,, Inc.

PubMed search: (cutaneous) leiomyosarcoma [title] skin

Christopher S. Hale, M.D.
Page views in 2019: 820
Page views in 2020 to date: 1,275
Cite this page: Hale C. Leiomyosarcoma. website. Accessed October 24th, 2020.
Definition / general
  • Malignant smooth muscle tumor similar to counterparts elsewhere
  • Typically larger than leiomyomas with vascular invasion
  • Recurs, but only rarely metastasizes
  • May be associated with HIV infection
Case reports
Microscopic (histologic) description
  • Cellular lesions of smooth muscle type cells with atypia, necrosis and mitotic activity
  • May have prominent vascular pattern, clear cell features, desmoplasia
Microscopic (histologic) images
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Various images

Positive stains
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