Skin nonmelanocytic tumor
Neural tumors
Malignant peripheral nerve sheath tumor (MPNST)


Topic Completed: 1 September 2012

Revised: 17 April 2019

Copyright: 2001-2019, PathologyOutlines.com, Inc.

PubMed search: "malignant peripheral nerve sheath tumor" [title] OR MPNST [title] skin

Christopher S. Hale, M.D.
Page views in 2018: 553
Page views in 2019 to date: 623
Cite this page: Hale CS. Malignant peripheral nerve sheath tumor (MPNST). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skintumornonmelanocyticMPNST.html. Accessed December 5th, 2019.
Definition / general
  • More common in deep soft tissue (see Soft Tissue chapter) but also present in skin
  • May be associated with neurofibromatosis type I
  • p53 expression may correlate with worse prognosis (Neuro Oncol 2009;11:514)
Case reports
Microscopic (histologic) description
  • Hypercellular, plexiform fascicles of neural cells, high mitotic activity, significant pleomorphism
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Molecular / cytogenetics description
  • Numerous cytogenetic abnormalities
  • Triploidy common
  • Most frequent translocations are 7p22 and 1p21, 7p11 and 14q11 (not necessarily cutaneous tumors, Int J Cancer 1995;61:793)
Back to top