Skin - Nonmelanocytic tumors
Other tumors of skin
Malignant peripheral nerve sheath tumor (MPNST)

Author: Christopher Hale, M.D. (see Authors page)

Revised: 5 October 2016, last major update September 2012

Copyright: (c) 2001-2016,, Inc.

PubMed search: "malignant peripheral nerve sheath tumor" [title] OR MPNST [title] skin

Cite this page: Malignant peripheral nerve sheath tumor (MPNST). website. Accessed October 17th, 2018.
Definition / general
  • More common in deep soft tissue (see Soft Tissue chapter) but also present in skin
  • May be associated with neurofibromatosis type I
  • p53 expression may correlate with worse prognosis (Neuro Oncol 2009;11:514)
Case reports
Microscopic (histologic) description
  • Hypercellular, plexiform fascicles of neural cells, high mitotic activity, significant pleomorphism
Microscopic (histologic) images
Images hosted on other servers:

Various images

Positive stains
Molecular / cytogenetics description
  • Numerous cytogenetic abnormalities
  • Triploidy common
  • Most frequent translocations are 7p22 and 1p21, 7p11 and 14q11 (not necessarily cutaneous tumors, Int J Cancer 1995;61:793)