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Skin - Nonmelanocytic tumors

Lymphoma and related disorders

NK/T cell lymphoma, extranodal, nasal type


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 16 July 2012, last major update July 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Aggressive tumors, usually in GI tract, less commonly in skin
● More common in Asia and South American than Western countries
● Estimated 5 year survival: 0%

Case reports
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● 77 year old woman with an indolent course for more than 22 years (Am J Dermatopathol 2012;34:194)

Micro description
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● May involve epidermis, dermis or subcutis
● Polymorphous lymphoid infiltrate with eosinophils, plasma cells, histiocytes
● Lymphocytes are usually large pleomorphic cells with vesicular nuclei and prominent nucleoli
● Also medium or small with irregular nuclei
● Usually angiocentric (52%) with necrosis (62%)
● Apoptosis common
● Occasionally clear cytoplasm

Micro images
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Tumor from various sites, including skin

Positive stains
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● CD2, CD3epsilon, CD56, TIA, granzyme B, EBER by ISH

Negative stains
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● CD20

Additional references
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● Skin and other sites (Mod Pathol 2004;17:1097)
Adv Hematol 2010;2010:627401

End of Skin - Nonmelanocytic tumors > Lymphoma and related disorders > NK/T cell lymphoma, extranodal, nasal type


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