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Skin - Nonmelanocytic tumors

Vascular tumors

Acquired (tufted) angioma


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 16 July 2012, last major update July 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Also called Nakagawa’s angioblastoma
● Benign, juvenile or infantile hemangioendothelioma
● May be the same entity as kaposiform hemangioendothelioma
● Slowly enlarging multiple red plaques on shoulders and upper back of children or teenagers

Case reports
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● Congenital tumor (Dermatology Online Journal 16;5:2)
● 2 month old boy with erythematous induration (Ann Dermatol 2010;22:426)

Clinical images
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Various images

Gross description
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● Subcutaneous dusky red nodule

Micro description
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● Multiple vascular lobules similar to pyogenic granuloma but more cellular, resembling cannonballs, and with semilunar vessel at periphery of lobule (versus central and open vessel in pyogenic granuloma)
● Variable mitotic figures, no atypia

Micro images
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(A) Cannon ball distribution of small discrete vascular tufts are found throughout the dermis
(B) A lobule composed of bloodless aggregates of round dilated capillaries surrounded by crescent-shaped vascular structures


Positive stains
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● Ulex europaeus and factor VIII related antigen only in endothelium of larger vascular channels

Differential diagnosis
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● Hemangioma, pyogenic granuloma, sarcoma

End of Skin - Nonmelanocytic tumors > Vascular tumors > Acquired (tufted) angioma


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