Skin - Nonmelanocytic tumors
Vascular tumors
Acquired tufted angioma

Author: Joel Tjarks, M.D. (see Authors page)

Revised: 27 July 2016, last major update July 2016

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Acquired tufted angioma

Definition / General
  • Benign vascular tumor most often arising in infancy or early childhood
Essential Features
  • Tufts of capillaries infiltrating the dermis and subcutaneous adipose tissue in a “cannonball” or lobular pattern
  • Considered to be on the same neoplastic spectrum as Kaposiform hemangioendothelioma; some consider it to be the same entity
Terminology
  • Synonyms: Tufted angioma, Nakagawa’s angioblastoma, progressive capillary hemangioma, tufted hemangioma
Epidemiology
  • Commonly affects children and young adults with no gender predilection
  • Rare cases have been reported in adults
  • May be seen in association with Kasabach-Merritt syndrome
  • Some cases have been associated with liver transplantation and pregnancy
Sites
  • Commonly found on neck, shoulders and trunk
  • Cranial and facial lesions are uncommon
Clinical Features
  • Erythematous, poorly defined mottled macules and plaques typically ranging from 2 - 5 cm
  • Usually solitary
  • Slowly growing lesion
  • Spontaneous regression rarely occurs
Treatment
  • Surgical excision for small lesions
  • Low dose aspirin, high dose steroids
  • Pulsed dye laser, chemotherapy (vincristine)
Clinical Images

Images hosted on PathOut servers:

Courtesy of Mark R. Wick, M.D.



Images hosted on other servers:

Wide tufted angioma
and Kasabach-Merritt
syndrome in patient
11 at age 6 months

Various images

Micro Description
  • Scattered lobules of small capillary type vessels with small oval to spindle-shaped cells throughout the dermis and subcutaneous tissue imparting a “cannonball” or glomerular appearance
  • May have variable mitoses without nuclear atypia
Micro Images

Images hosted on PathOut servers:

Courtesy of Joel Tjarks, M.D.



Courtesy of Mark R. Wick, M.D.



Images hosted on other servers:

Cannon ball distribution

Positive Stains
  • CD31, CD34
  • D2-40 highlights surrounding dilated dermal lymphatics
Negative Stains