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Skin - Nonmelanocytic tumors

Carcinoma (non-adnexal)

Adenoid squamous cell carcinoma

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 15 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.


● Also called pseudoglandular, pseudoangiosarcomatous, or acantholytic squamous cell carcinoma
● Due to a desmosomal defect that causes lack of cell adhesion (acantholysis)
● May resemble angiosarcoma
● Usually sun-exposed skin, often associated with actinic keratosis with acantholysis
● Does NOT appear to be a more aggressive tumor (Dermatol Surg 2011;37:353)

Case reports

● 57 year old woman with vulvar ASCC (Int J Gynecol Pathol 2008;27:288)

Micro description

● Invasive, tubular or pseudoglandular profiles of polygonal cells in the dermis, with glassy eosinophilic cytoplasm and focal squamous pearl formation; usually connections to overlying epidermis (J Cutan Pathol 1989;16:114)

Differential diagnosis

● Adenocarcinoma (primary or metastatic)
● Adenosquamous carcinoma

End of Skin - Nonmelanocytic tumors > Carcinoma (non-adnexal) > Adenoid squamous cell carcinoma

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