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Skin - Nonmelanocytic tumors

Carcinoma (non-adnexal)

Adenosquamous carcinoma

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 15 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.


● Rare, aggressive
● Usually men with lesions on face, scalp or upper extremities (Arch Dermatol 2009;145:1152)

Clinical images

Recurrent adenosquamous carcinoma of shoulder; intraoperative view (fig B) shows gross residual tumor designated by clamp

Micro description

● Squamous differentiation and mucin production

Micro images

Figure A: Infiltrative pattern of neoplastic nests, dermal fibrosis/sclerosis, elastosis, and focal ulceration (asterisk); Figure B: Keratinizing cysts (small arrow) and glandular elements (large arrow)

Figure A: CK903 stains neoplastic cells diffusely; Figure B: CEA highlights glandular differentiation

Differential diagnosis

● Adenocarcinoma (primary vs. metastatic)

End of Skin - Nonmelanocytic tumors > Carcinoma (non-adnexal) > Adenosquamous carcinoma

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