Skin nonmelanocytic tumor
Lymphoma and related disorders - T cell / NK cell neoplasms
Anaplastic large cell lymphoma


Topic Completed: 1 July 2012

Revised: 12 April 2019

Copyright: 2001-2019, PathologyOutlines.com, Inc.

PubMed search: cutaneous [title] OR dermal [title] "anaplastic large cell lymphoma"
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Cite this page: Hale C. Anaplastic large cell lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skintumornonmelanocyticanaplasticlargecell.html. Accessed April 26th, 2019.
Definition / general
  • Usually elderly men
  • Either primary cutaneous, systemic ALK+ or systemic ALK negative
  • Primary cutaneous tumor has good prognosis
  • May have regressive phase
Case reports
Clinical images

Images hosted on other servers:

Annular, erythematous
to violaceous indurated
plaques with fixed
nodules over arm
Gross description
  • Solitary or multiple lesions
Microscopic (histologic) description
  • Large anaplastic tumor cells infiltrate dermis and subcutis, may resemble lymphomatoid papulosis, often pseudoepitheliomatous hyperplasia
  • Variants: Hodgkin’s-like, lymphohistiocytic, monomorphic, myxoid, neutrophil rich (associated with HIV+), sarcomatoid, small cell
Microscopic (histologic) images

Case of the Week #415



CD30

Ki67



Images hosted on other servers:

Various images

Positive stains
  • CD30 (diffuse membrane and paranuclear dot-like staining)
  • Usually T cell markers
Negative staining - disease
Molecular / cytogenetics description
  • t(2;5) is usually NOT present
Differential diagnosis
  • CD30+ nonneoplastic cutaneous infiltrates
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