Skin - Nonmelanocytic tumors
Lymphoma and related disorders
Anaplastic large cell lymphoma

Author: Christopher Hale, M.D. (see Authors page)

Revised: 14 October 2016, last major update July 2012

Copyright: (c) 2001-2016,, Inc.

PubMed search: cutaneous [title] OR dermal [title] "anaplastic large cell lymphoma"

Cite this page: Anaplastic large cell lymphoma. website. Accessed October 26th, 2016.
Definition / General
  • Usually elderly men
  • Either primary cutaneous, systemic ALK+ or systemic ALK negative
  • Primary cutaneous tumor has good prognosis
  • May have regressive phase
Case Reports
Clinical Images
Images hosted on other servers:

Annular, erythematous
to violaceous indurated
plaques with fixed
nodules over arm
Gross Description
  • Solitary or multiple lesions
Micro Description
  • Large anaplastic tumor cells infiltrate dermis and subcutis, may resemble lymphomatoid papulosis, often pseudoepitheliomatous hyperplasia
  • Variants: Hodgkin’s-like, lymphohistiocytic, monomorphic, myxoid, neutrophil rich (associated with HIV+), sarcomatoid, small cell
Micro Images
Images hosted on other servers:

Various images

Positive Stains
  • CD30 (diffuse membrane and paranuclear dot-like staining)
  • Usually T cell markers, NPM-ALK transcript
Molecular / Cytogenetics Description
  • t(2;5) generates NPM-ALK fusion transcript
Differential Diagnosis
  • CD30+ nonneoplastic cutaneous infiltrates