Home   Chapter Home   Jobs   Conferences   Fellowships   Books

Advertisement

Skin - Nonmelanocytic tumors

Lymphoma and related disorders

Anaplastic large cell lymphoma

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 15 July 2012, last major update July 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Usually elderly men
● Either primary cutaneous, systemic ALK+ or systemic ALK negative
● Primary cutaneous tumor has good prognosis
● May have regressive phase

Case reports
=========================================================================

● 47 year old female with plaques on arm (J Dermatol Case Rep 2008;2:31)

Clinical images
=========================================================================

Annular, erythematous to violaceous indurated plaques with fixed nodules over arm

Gross description
=========================================================================

● Solitary or multiple lesions

Micro description
=========================================================================

● Large anaplastic tumor cells infiltrate dermis and subcutis, may resemble lymphomatoid papulosis, often pseudoepitheliomatous hyperplasia
● Variants: Hodgkin’s-like, lymphohistiocytic, monomorphic, myxoid, neutrophil-rich (associated with HIV+), sarcomatoid, small cell

Micro images
=========================================================================

               
Various images

Positive stains
=========================================================================

● CD30 (diffuse membrane and paranuclear dot-like staining)
● Usually T cell markers, NPM-ALK transcript

Molecular
=========================================================================

● t(2;5) generates NPM-ALK fusion transcript

Differential diagnosis
=========================================================================

● CD30+ non-neoplastic cutaneous infiltrates

Additional references
=========================================================================

● Adv Hematol 2010;345053 Epub 2011 Feb 6

End of Skin - Nonmelanocytic tumors > Lymphoma and related disorders > Anaplastic large cell lymphoma

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).