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Skin - Nonmelanocytic tumors

Lymphoma and related disorders

Anaplastic large cell lymphoma


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 15 July 2012, last major update July 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Usually elderly men
● Either primary cutaneous, systemic ALK+ or systemic ALK negative
● Primary cutaneous tumor has good prognosis
● May have regressive phase

Case reports
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● 47 year old female with plaques on arm (J Dermatol Case Rep 2008;2:31)

Clinical images
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Annular, erythematous to violaceous indurated plaques with fixed nodules over arm

Gross description
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● Solitary or multiple lesions

Micro description
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● Large anaplastic tumor cells infiltrate dermis and subcutis, may resemble lymphomatoid papulosis, often pseudoepitheliomatous hyperplasia
● Variants: Hodgkin’s-like, lymphohistiocytic, monomorphic, myxoid, neutrophil-rich (associated with HIV+), sarcomatoid, small cell

Micro images
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Various images

Positive stains
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● CD30 (diffuse membrane and paranuclear dot-like staining)
● Usually T cell markers, NPM-ALK transcript

Molecular
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● t(2;5) generates NPM-ALK fusion transcript

Differential diagnosis
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● CD30+ non-neoplastic cutaneous infiltrates

Additional references
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Adv Hematol 2010;345053 Epub 2011 Feb 6

End of Skin - Nonmelanocytic tumors > Lymphoma and related disorders > Anaplastic large cell lymphoma


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