Skin - Nonmelanocytic tumors
Lymphoma and related disorders
Anaplastic large cell lymphoma

Topic Completed: 1 July 2012

Revised: 8 February 2019

Copyright: 2001-2017,, Inc.

PubMed search: cutaneous [title] OR dermal [title] "anaplastic large cell lymphoma"

Page views in 2018: 711
Page views in 2019 to date: 170
Cite this page: Hale C. Anaplastic large cell lymphoma. website. Accessed February 17th, 2019.
Definition / general
  • Usually elderly men
  • Either primary cutaneous, systemic ALK+ or systemic ALK negative
  • Primary cutaneous tumor has good prognosis
  • May have regressive phase
Case reports
Clinical images
Images hosted on other servers:

Annular, erythematous
to violaceous indurated
plaques with fixed
nodules over arm
Gross description
  • Solitary or multiple lesions
Microscopic (histologic) description
  • Large anaplastic tumor cells infiltrate dermis and subcutis, may resemble lymphomatoid papulosis, often pseudoepitheliomatous hyperplasia
  • Variants: Hodgkin’s-like, lymphohistiocytic, monomorphic, myxoid, neutrophil rich (associated with HIV+), sarcomatoid, small cell
Microscopic (histologic) images
Images hosted on PathOut server:

Case of the Week #415

Case of the Week #415

CD30, COW #415

Ki-67, COW #415

Images hosted on other servers:

Various images

Positive stains
  • CD30 (diffuse membrane and paranuclear dot-like staining)
  • Usually T cell markers
Negative staining - disease
Molecular / cytogenetics description
  • t(2;5) is usually NOT present
Differential diagnosis
  • CD30+ nonneoplastic cutaneous infiltrates