Skin nonmelanocytic tumors
Lymphoma and related disorders
Angiocentric lymphoma

Author: Christopher Hale, M.D. (see Authors page)

Revised: 14 September 2018, last major update June 2012

Copyright: (c) 2001-2018,, Inc.

PubMed search: angiocentric [title] lymphoma skin

Cite this page: Hale, C. Angiocentric lymphoma. website. Accessed October 16th, 2018.
Definition / general
  • Affects gastrointestinal tract, skin, nasal cavities and pharynx

Also known as:
  • Extranodal natural killer cell lymphoma
  • Nasal type NK lymphoma
  • NK / T cell lymphoma
  • Polymorphic / malignant midline reticulosis
  • Lethal midline granuloma
Case reports
  • 5 patients with primary cutaneous NK / T cell (angiocentric) lymphoma (Blood 2010;116:165)
Clinical images

Images hosted on other servers:

Various images

Gross description
  • Multiple plaques, nodules or ulcerated nodules
Microscopic (histologic) description
  • Perivascular to diffuse dermal infiltrate with vascular invasion in 50%, also perineural invasion, adnexal destruction, extensive necrosis
  • Epidermis is uninvolved
  • Infiltrate composed of atypical and normal appearing lymphocytes, plasma cells, histiocytes
  • Atypical lymphocytes are high grade malignant cells
Microscopic (histologic) images

Images hosted on other servers:

H&E and immunostains

Positive stains
  • Usually T cell markers, CD56
Additional references