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Skin - Nonmelanocytic tumors

Lymphoma and related disorders

Angiocentric lymphoma


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 15 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Affects gastrointestinal tract, skin, nasal cavities and pharynx

Also known as:
● Extranodal natural killer cell lymphoma
● Nasal-type NK lymphoma
● NK/T-cell lymphoma
● Polymorphic/malignant midline reticulosis
● Lethal midline granuloma

Case reports
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● 5 patients with primary cutaneous NK/T-cell (angiocentric) lymphoma (Blood 2010;116:165)

Clinical images
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Various images

Gross description
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● Multiple plaques, nodules or ulcerated nodules

Micro description
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● Perivascular to diffuse dermal infiltrate with vascular invasion in 50%, also perineural invasion, adnexal destruction, extensive necrosis
● Epidermis is uninvolved
● Infiltrate composed of atypical and normal appearing lymphocytes, plasma cells, histiocytes
● Atypical lymphocytes are high grade malignant cells

Micro images
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H&E and immunostains

Positive stains
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● Usually T cell markers, CD56

Additional references
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J Clin Oncol 2001;19:2179

End of Skin - Nonmelanocytic tumors > Lymphoma and related disorders > Angiocentric lymphoma


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