Skin nonmelanocytic tumor
Lymphoma and related disorders - T cell / NK cell neoplasms
Angiocentric lymphoma

Topic Completed: 1 June 2012

Revised: 12 April 2019

Copyright: 2001-2019,, Inc.

PubMed search: angiocentric [title] lymphoma skin

Christopher S. Hale, M.D.
Page views in 2018: 481
Page views in 2019 to date: 733
Cite this page: Hale CS. Angiocentric lymphoma. website. Accessed December 8th, 2019.
Definition / general
  • Affects gastrointestinal tract, skin, nasal cavities and pharynx

Also known as:
  • Extranodal natural killer cell lymphoma
  • Nasal type NK lymphoma
  • NK / T cell lymphoma
  • Polymorphic / malignant midline reticulosis
  • Lethal midline granuloma
Case reports
  • 5 patients with primary cutaneous NK / T cell (angiocentric) lymphoma (Blood 2010;116:165)
Clinical images

Images hosted on other servers:

Various images

Gross description
  • Multiple plaques, nodules or ulcerated nodules
Microscopic (histologic) description
  • Perivascular to diffuse dermal infiltrate with vascular invasion in 50%, also perineural invasion, adnexal destruction, extensive necrosis
  • Epidermis is uninvolved
  • Infiltrate composed of atypical and normal appearing lymphocytes, plasma cells, histiocytes
  • Atypical lymphocytes are high grade malignant cells
Microscopic (histologic) images

Images hosted on other servers:

H&E and immunostains

Positive stains
  • Usually T cell markers, CD56
Additional references
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