Skin tumor - Nonmelanocytic - Apocrine cystadenoma

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Skin - Nonmelanocytic tumors

Cysts

Apocrine cystadenoma

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 29 June 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Small (<2 cm), usually face of older adults
● Solitary or multiple, skin-colored or blue-black
● Lined by sweat duct-like epithelium which may have apocrine features (“snouting” or “decapitation secretion”)

Gross description
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● Unilocular cystic lesion with clear to brown fluid

Micro images
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Apocrine cystadenoma

Electron microscopy description
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● Two types of cells: secretory with granules having features of lipid droplets and basal (myoepithelial) cells
● Lumen filled with fragments of cytoplasm detached from the apical portions of secretory cells (Arch Dermatol 1979;115:194)

Positive stains
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● AE1/AE3

Negative stains
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● 34betaE12 (J Cutan Pathol 1999;26:295)

Differential diagnosis
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● Eccrine cystadenoma

End of Skin - Nonmelanocytic tumors > Cysts > Apocrine cystadenoma

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