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Skin - Nonmelanocytic tumors

Adnexal tumors - apocrine glands

Apocrine mixed tumor

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 3 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.


● Similar to eccrine mixed tumor of skin
● Head/neck region > extremities/back/trunk

Gross description

● Painless, firm, nodule

Micro description

● Epithelial component: elongated branching tubular structures with two cell layers
● Inner layer is columnar with eosinophilic cytoplasm
● “Decapitation” type secretion, often squamous metaplasia and basal nuclei
● May have areas of apocrine, follicular and sebaceous differentiation
● Rarely has intravascular tumor deposits (Am J Dermatopathol 2011;33:775)

Positive stains

● Stromal cells: S100, vimentin, NSE, GFAP, SMA, calponin, p63

Negative stains

● Desmin (usually, J Clin Pathol 2007;60:145)

Differential diagnosis

Eccrine mixed tumor/chondroid syringoma: myoepithelial and epithelial type cells, some with abundant hyaline cytoplasm, in chrondomyxoid stroma; no decapitation like secretion
● Metastatic carcinoma
● Other adnexal tumors with apocrine differentiation

End of Skin - Nonmelanocytic tumors > Adnexal tumors - apocrine glands > Apocrine mixed tumor

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