Skin tumor - Nonmelanocytic - Apocrine tubular adenoma

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Skin - Nonmelanocytic tumors

Adnexal tumors - apocrine glands

Apocrine tubular adenoma

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 2 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Well-defined nodule, usually < 2 cm and on scalp
● Rarely nose, eyelid, chest, external auditory meatus, cheek, vulva

Case reports
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● 61 year old female with 6 month history of solitary nodule on nose (Eur J Dermatol 2011 21:132)

Gross description
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● Firm, skin-colored nodule

Micro description
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● Lobular pattern of dermal and subcutaneous tubular apocrine structures with epidermal connection
● Resembles papillary syringadenoma

Micro images
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Tubular apocrine adenoma—an unusual eyelid tumour

Electron macroscopy description
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● Tall columnar cells on basal lamina forming acini
● Luminal cells with granules and microvilli
● Decapitation secretion (J Am Acad Dermatol 1984;11:639)

Positive stains
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● EMA, CAM5.2 (luminal surface of tubules), SMA (outer tubules), GCDFP-15 (focal diffuse cytoplasmic), CK7

Negative stains
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● AR (Eur J Dermatol 2011;21:132)

Differential diagnosis
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● Syringocystadenoma papilliferum

End of Skin - Nonmelanocytic tumors > Adnexal tumors - apocrine glands > Apocrine tubular adenoma

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