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Skin - Nonmelanocytic tumors

Premalignant or noninvasive

Bowenoid papulosis

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 4 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Multiple pigmented papular lesions of anogenital area, usually in young adults, resembling condyloma acuminatum
● May regress spontaneously
● Almost never invasive

Case reports
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● Two patients treated by Tazarotene (Indian J Dermatol 2009;54:283)

Clinical images
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Penile shaft

       
Vulvar images

Gross description
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● Flat papules on anogenital skin

Micro description
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● Resembles carcinoma in situ, but with localized acanthosis similar to condylomas
● Low power view is “salt and pepper” due to dark nuclei and clear vacuolar cytoplasm
● Usually no adnexal involvement

Micro images
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Acanthosis and dyskeratosis

Positive stains
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● HPV

Molecular
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● HPV type 16 is most common

Differential diagnosis
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● Actinic keratosis

End of Skin - Nonmelanocytic tumors > Premalignant or noninvasive > Bowenoid papulosis

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