Skin tumor - Nonmelanocytic - Bowen’s disease

Home Chapter Home Jobs Conferences Fellowships Books

Skin - Nonmelanocytic tumors

Premalignant or noninvasive

Bowen’s disease

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 4 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Usually on skin NOT exposed to sunlight, such as trunk
● Called erythroplasia (of Queyrat) if at glans penis, vulva, oral cavity
● Often considered as carcinoma in situ or squamous intraepidermal neoplasia

Case reports
=========================================================================

● 36 year old man with pigmented Bowen’s disease (Ann Dermatol 2009;21:197)

Clinical images
=========================================================================

Solitary black colored verrucous scaly plaque on umbilicus

Erythematous scaly plaque with crusting on palm

Gross description
=========================================================================

● Slightly raised, large scaly erythematous plaque with irregular border
● Usually single patch or verrucous growth

Micro description
=========================================================================

● Atypia is prominent and throughout epidermis
● Includes nuclear hyperchromasia and multinucleation, individual cell dyskeratosis, increased mitotic figures, atypical mitotic figures
● Also cytoplasmic vacuoles, markedly altered maturation, but usually still some surface keratinization
● May extend into eccrine sweat glands (not considered invasive disease)
● Intercellular bridges present
● Rarely pagetoid cells or ground glass cytoplasm

Micro images
=========================================================================

Contributed by Dr. Amy Lynn, Toledo, Ohio

Various images

Positive stains
=========================================================================

● p53, HPV, high molecular weight cytokeratin

Molecular
=========================================================================

● Aneuploid

Differential diagnosis
=========================================================================

● Bowenoid actinic keratosis: circumscribed, in sun-exposed areas with clinical appearance of actinic keratosis
● Chronic arsenic ingestion

End of Skin - Nonmelanocytic tumors > Premalignant or noninvasive > Bowen’s disease

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).