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Skin - Nonmelanocytic tumors

Adnexal tumors - eccrine sweat glands

Clear cell acanthoma


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 3 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Also called pale cell acanthoma (of Degos)
● Legs, usually females, rarely may be multiple (eruptive)
Acanthoma: broad term for benign tumor of keratinocytes

Clinical images
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Clear cell acanthoma

Gross description
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● Pink to brown, flat or slightly raised plaque or nodule
● Peripheral collarette of scale

Micro description
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● Bland, intraepithelial tumor of clear keratinocytes with dermal inflammation and abrupt transition to normal epidermis
● May have melanocytic proliferation, psoriasiform acanthosis, parakeratosis

Micro images
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Sharply-demarcated lesion within epidermis has nodular configuration with flat, non-infiltrative base; cells are very pale or clear.


Abrupt change in epidermis is present at edge of lesion; cells are clearly keratinocytes with prominent intercellular bridges, but cytoplasm is pale (glycogenated); no significant atypia; Also overlying parakeratotic scale with occasional inflammatory cells

Positive stains
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● Glycogen

Differential diagnosis
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● Seborrheic keratosis
● Bowen disease
● Poroma

End of Skin - Nonmelanocytic tumors > Adnexal tumors - eccrine sweat glands > Clear cell acanthoma


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