Skin - Nonmelanocytic tumors
Lymphoma and related disorders

Author: Christopher Hale, M.D. (see Authors page)

Revised: 16 October 2016, last major update June 2012

Copyright: (c) 2001-2016,, Inc.

PubMed search: cutaneous [title] OR dermal [title] lymphoma skin

Cite this page: General. website. Accessed October 20th, 2016.
Definition / General
  • See also Lymphoma chapter
  • Equal incidence of B and T cell disorders (noncutaneous lymphomas have B cell predominance)
  • May be primary to skin or part of systemic disease
  • Common primary cutaneous lymphomas are: T cell - mycosis fungoides; B cell - diffuse large B cell lymphoma, extranodal marginal zone lymphoma, follicular lymphoma
  • Note: lymphocytes in skin are significant, since not usually present, although may be due to dermatoses
  • Angiocentric: lymphomatoid granulomatosis, nasal type NK / T cell lymphoma
  • Dermal involvement: blastic NK cell lymphoma, CD30+/- large T cell lymphoma, diffuse large B cell lymphoma, follicular center cell lymphoma, granulomatous slack skin disease, inflammatory pseudotumor, lymphoid hyperplasia, lymphomatoid papulosis, marginal zone lymphoma, plasmacytoma, pleomorphic small / medium sized T cell lymphoma
  • Dermal - superficial: Sézary syndrome
  • Epidermotropic: adult T cell leukemia / lymphoma, mycosis fungoides, mycosis fungoides associated follicular mucinosis, pagetoid reticulosis
  • Intravascular: intravascular large B cell lymphoma
  • Subcutaneous: subcutaneous panniculitis-like T cell lymphoma
Micro Description
  • B cell lymphomas: triangular architecture with base in subcutis, compact and nodular infiltrates with perivascular cuffing; epidermis not involved
  • T cell lymphomas: heterogenous; may have epidermal involvement; may have large reactive component mixed with tumor cells
Additional References