Home   Chapter Home   Jobs   Conferences   Fellowships   Books


Skin - Nonmelanocytic tumors

Lymphoma and related disorders


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 15 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.


● See also Lymphoma chapter
● Equal incidence of B and T cell disorders (noncutaneous lymphomas have B cell predominance)
● May be primary to skin or part of systemic disease
● Common primary cutaneous lymphomas are: T cell - mycosis fungoides; B cell - diffuse large B cell lymphoma, extranodal marginal zone lymphoma, follicular lymphoma
Note: lymphocytes in skin are significant, since not usually present, although may be due to dermatoses

Classification clues

Angiocentric: lymphomatoid granulomatosis, nasal type NK/T cell lymphoma
Dermal involvement: blastic NK cell lymphoma, CD30+/- large T cell lymphoma, diffuse large B cell lymphoma, follicular center cell lymphoma, granulomatous slack skin disease, inflammatory pseudotumor, lymphoid hyperplasia, lymphomatoid papulosis, marginal zone lymphoma, plasmacytoma, pleomorphic small/medium-sized T cell lymphoma
Dermal-superficial: SÚzary syndrome
Epidermotropic: adult T cell leukemia / lymphoma, mycosis fungoides, mycosis fungoides associated follicular mucinosis, pagetoid reticulosis
Intravascular: intravascular large B cell lymphoma
Subcutaneous: subcutaneous panniculitis-like T cell lymphoma

Micro description

B cell lymphomas: triangular architecture with base in subcutis, compact and nodular infiltrates with perivascular cuffing; epidermis not involved
T cell lymphomas: heterogenous; may have epidermal involvement; may have large reactive component mixed with tumor cells

Additional references

Br J Dermatol 2005;153:874

End of Skin - Nonmelanocytic tumors > Lymphoma and related disorders > General

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at [email protected] with any questions (click here for other contact information).