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Skin - Nonmelanocytic tumors
Lymphoma and related disorders
General
Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 15 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.
General
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● See also Lymphoma chapter
● Equal incidence of B and T cell disorders (noncutaneous lymphomas have B cell predominance)
● May be primary to skin or part of systemic disease
● Common primary cutaneous lymphomas are: T cell - mycosis fungoides; B cell - diffuse large B cell lymphoma, extranodal marginal zone lymphoma, follicular lymphoma
● Note: lymphocytes in skin are significant, since not usually present, although may be due to dermatoses
Classification clues
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● Angiocentric: lymphomatoid granulomatosis, nasal type NK/T cell lymphoma
● Dermal involvement: blastic NK cell lymphoma, CD30+/- large T cell lymphoma, diffuse large B cell lymphoma, follicular center cell lymphoma, granulomatous slack skin disease, inflammatory pseudotumor, lymphoid hyperplasia, lymphomatoid papulosis, marginal zone lymphoma, plasmacytoma, pleomorphic small/medium-sized T cell lymphoma
● Dermal-superficial: Sézary syndrome
● Epidermotropic: adult T cell leukemia / lymphoma, mycosis fungoides, mycosis fungoides associated follicular mucinosis, pagetoid reticulosis
● Intravascular: intravascular large B cell lymphoma
● Subcutaneous: subcutaneous panniculitis-like T cell lymphoma
Micro description
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● B cell lymphomas: triangular architecture with base in subcutis, compact and nodular infiltrates with perivascular cuffing; epidermis not involved
● T cell lymphomas: heterogenous; may have epidermal involvement; may have large reactive component mixed with tumor cells
Additional references
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End of Skin - Nonmelanocytic tumors > Lymphoma and related disorders > General
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