Skin - Nonmelanocytic tumors
Other tumors of skin
Deep benign fibrous histiocytoma

Author: Christopher Hale, M.D., Vijay Shankar, M.D. (see Authors page)

Revised: 13 September 2016, last major update August 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Deep benign fibrous histiocytoma

Cite this page: Deep benign fibrous histiocytoma. website. Accessed October 25th, 2016.
Definition / General
  • Benign fibrous histiocytoma of subcutaneous tissue, deep soft tissue or parenchymal organs, with no dermal involvement (Am J Surg Pathol 1994;18:677, Am J Surg Pathol 1990;14:801, Stanford Medicine)
  • Rare painless lesions, < 1% of fibrohistiocytic tumors
  • Usually adult males > 25 years (range 6 - 84 years)
  • Usually extremities, head and neck, trunk; rarely in deep soft tissue of retroperitoneum, mediastinum or pelvis
Case Reports
Clinical Images

Images hosted on other servers:

Nodule in arch of foot

Gross Description
  • Well circumscribed with pseudocapsule, typically 4 cm (range 0.5 to 25 cm), variable hemorrhage
Micro Description
  • Prominent storiform pattern of uniform spindle cells with ill defined eosinophilic cytoplasm and bland, elongated or plump vesicular nuclei with no atypia
  • Often hemangiopericytoma-like vasculature
  • Scattered lymphocytes, either multinucleated giant cells, osteoclastic giant cells or foam cells in 59%
  • Usually less than 5 mitotic figures / 10 HPF
  • Stroma is myxoid or hyaline
  • Borders are non-infiltrative, with no trapping of fat cells
  • Necrosis or angiolymphatic invasion are rare
Micro Images

Images hosted on PathOut servers:

Circumscribed tumor with no trapped fat

Cellular tumor

Tumor with more fibrous stroma

Foam cells help distinguish from DFSP

Focal storiform pattern and cellular uniformity

Hemangiopericytoma-like vascular pattern

Case of the Week #360

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Various images

Positive Stains
Negative Stains
Differential Diagnosis