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Skin - Nonmelanocytic tumors

Other tumors of skin

Dermatomyofibroma

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 14 September 2012, last major update September 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Distinct cutaneous plaque-like proliferation of fibroblasts and myofibroblasts (J Cutan Pathol 1992;19:85, Br J Dermatol 1993;129:69)
● Also called cutaneous myofibroma
● Women > men, usually age 20-39, but occasionally in children (J Cutan Pathol 2011;38;967)
● Upper arms, neck or trunk
● Pediatric cases more often in neck

Case reports
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● Four month old boy with plaque on trunk (Ann Dermatol 2011;23 Suppl 1:S72)
● Two young women with chest and back lesions (J Cutan Pathol 1994;21:371)

Clinical images
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Ill-defined bluish firm plaque on the left flank

Gross description
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● Red-brown plaque or nodule

Micro description
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● Fascicles of monomorphic spindle cells parallel to epidermis

Micro images
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H&E and smooth muscle actin

Positive stains
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● Alpha-smooth muscle actin, vimentin

Negative stains
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● S100, desmin, factor XIIIa, CD34

Differential diagnosis
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● Plaque-stage DFSP
● Dermatofibroma
● Keloid (gross)
● Diffuse neurofibroma
● Other tumors with myofibroblastic differentiation

End of Skin - Nonmelanocytic tumors > Other tumors of skin > Dermatomyofibroma

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