Skin nonmelanocytic tumor
Fibrous, fibrohistiocytic and myofibroblastic neoplasms
Myxoid variant of DFSP

Topic Completed: 1 September 2012

Revised: 18 April 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Myxoid variant of DFSP

See also: Dermatofibrosarcoma protuberans (DFSP), Sarcomas

Christopher S. Hale, M.D.
Page views in 2018: 1,309
Page views in 2019 to date: 1,258
Cite this page: Hale CS. Myxoid variant of DFSP. website. Accessed September 22nd, 2019.
Definition / general
  • DFSP with 50%+ myxoid stroma
  • Uncommon
  • Median age 40 years, male and female
  • Extremities, head and neck, trunk, anogenital region
  • Associated with recurrent tumor
  • Similar prognosis as classic DFSP (Am J Surg Pathol 2007;31:1371)
  • Should distinguish from post-traumatic CD34+ myxoid dermatofibrohistiocytoma (J Cutan Pathol 2009;36:84)
Case reports
Gross description
  • Median 3 cm, white-tan-gray-yellow, firm to gelatinous
Microscopic (histologic) description
  • Infiltrative, often hypocellular, sheet-like, bland spindle cells with pale eosinophilic cytoplasm, spindled nuclei, no pleomorphism
  • Stroma is myxoid with prominent thin walled vessels
  • Diffuse infiltration of fat
  • Also cellular areas typical of DFSP
Microscopic (histologic) images

Images hosted on PathOut server:

Courtesy of Mark R. Wick, M.D.

Case of the Week #132

Positive stains
Negative stains
Differential diagnosis
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