Skin nonmelanocytic tumors
Lymphoma and related disorders
Diffuse large B cell lymphoma

Author: Christopher Hale, M.D. (see Authors page)

Revised: 14 September 2018, last major update June 2012

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PubMed search: Diffuse large B-cell lymphoma [title] skin

Related topics: Leg type
Cite this page: Hale, C. Diffuse large B cell lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skintumornonmelanocyticdiffuselargeBcell.html. Accessed September 24th, 2018.
Definition / general
Case reports
  • 51 and 62 year old men with primary cutaneous T cell-rich B cell lymphoma (Mod Pathol 2001;14:10)
  • T(14;18)(q32;q21) involving MALT1 and IGH genes in an extranodal diffuse large B cell lymphoma (Hum Pathol 2003;34:1212)
Treatment
  • Surgery, localized radiotherapy
  • Systemic chemotherapy only for generalized skin lesions or disseminated lesions
Gross description
  • Solitary or grouped papules, plaques or tumors, usually in head, neck and trunk of older patients
Microscopic (histologic) description
  • Either:
    • Mixed large and small B cells
    • Grade 3 follicular lymphomas (usually in head / neck and CD10+) OR
    • Monomorphous large cell (Am J Surg Pathol 2001;25:307)
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Mark R. Wick, M.D.

Various images



Images hosted on other servers:

CD3, L26

Diffusely dense lymphocytic infiltrate

Positive stains
Negative stains
  • Tumor cells: CD3 (positive in background cells), CD10 (usually)
Flow cytometry description