Skin - Nonmelanocytic tumors
Adnexal tumors - eccrine sweat glands
Hidradenoma / eccrine acrospiroma

Author: Christopher Hale, M.D. (see Authors page)

Revised: 5 October 2016, last major update June 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Eccrine acrospiroma [title]

Cite this page: Hidradenoma / eccrine acrospiroma. website. Accessed October 19th, 2018.
Definition / general
  • Commonly called hidradenoma (solid-cystic or nodular hidradenoma)
  • Arises from sweat gland distal excretory duct, usually solitary, on the scalp, axillae
Gross description
  • Nodules with cystic foci high in dermis
Microscopic (histologic) description
  • Nests / lobules of cells resembling eccrine poroma with either clear cytoplasm or prominent squamous metaplasia
  • May have marked vascularity
  • Small and large lumina are lined by cuboidal ductal cells or columnar secretory cells
  • Cystic spaces may be due to degeneration of tumor cells
Microscopic (histologic) images

Images hosted on other servers:

Courtesy of Angel Fernandez-Flores, M.D., Ph.D.

Breast skin - contributed by Mark R. Wick, M.D.

Positive stains
Differential diagnosis
  • Apocrine mixed tumor
  • Glomus tumor (different staining pattern)
  • Metastatic disease (renal cell carcinoma)
  • Primary skin tumors with follicular differentiation
  • Sebaceous differentiation, or sweat gland differentiation