Skin - Nonmelanocytic tumors
Adnexal tumors - eccrine sweat glands
Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 3 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.
● Commonly called hidradenoma (solid-cystic or nodular hidradenoma)
● Arises from sweat gland distal excretory duct, usually solitary, on the scalp, axillae
● Nodules with cystic foci high in dermis
● Nests/lobules of cells resembling eccrine poroma with either clear cytoplasm or prominent squamous metaplasia
● May have marked vascularity
● Small and large lumina are lined by cuboidal ductal cells or columnar secretory cells
● Cystic spaces may be due to degeneration of tumor cells
Contributed by Angel Fernandez-Flores, MD, PhD, Hospital El Bierzo and Clinica Ponferrada, Spain
● Keratin, EMA, CEA, S100, vimentin
● Apocrine mixed tumor
● Metastatic disease (renal cell carcinoma)
● Primary skin tumors with follicular differentiation
● Sebaceous differentiation, or sweat gland differentiation
● Glomus tumor (different staining pattern)
End of Skin - Nonmelanocytic tumors > Adnexal tumors - eccrine sweat glands > Eccrine acrospiroma
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