Skin nonmelanocytic tumor
Adnexal tumors - eccrine sweat glands
Nodular hidradenoma / eccrine acrospiroma


Topic Completed: 1 June 2012

Revised: 29 March 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Eccrine acrospiroma [title]
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Cite this page: Hale C. Nodular hidradenoma / eccrine acrospiroma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skintumornonmelanocyticeccrineacrospiroma.html. Accessed April 21st, 2019.
Definition / general
  • Commonly called hidradenoma (solid-cystic or nodular hidradenoma)
  • Arises from sweat gland distal excretory duct, usually solitary, on the scalp, axillae
Gross description
  • Nodules with cystic foci high in dermis
Microscopic (histologic) description
  • Nests / lobules of cells resembling eccrine poroma with either clear cytoplasm or prominent squamous metaplasia
  • May have marked vascularity
  • Small and large lumina are lined by cuboidal ductal cells or columnar secretory cells
  • Cystic spaces may be due to degeneration of tumor cells
Microscopic (histologic) images

Images hosted on other servers:

Courtesy of Angel Fernandez-Flores, M.D., Ph.D.



Breast skin - contributed by Mark R. Wick, M.D.

Positive stains
Differential diagnosis
  • Apocrine mixed tumor
  • Glomus tumor (different staining pattern)
  • Metastatic disease (renal cell carcinoma)
  • Primary skin tumors with follicular differentiation
  • Sebaceous differentiation, or sweat gland differentiation
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