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Skin - Nonmelanocytic tumors

Adnexal tumors - eccrine sweat glands

Eccrine acrospiroma

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 3 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.


● Commonly called hidradenoma (solid-cystic or nodular hidradenoma)
● Arises from sweat gland distal excretory duct, usually solitary, on the scalp, axillae

Gross description

● Nodules with cystic foci high in dermis

Micro description

● Nests/lobules of cells resembling eccrine poroma with either clear cytoplasm or prominent squamous metaplasia
● May have marked vascularity
● Small and large lumina are lined by cuboidal ductal cells or columnar secretory cells
● Cystic spaces may be due to degeneration of tumor cells

Micro images

Contributed by Angel Fernandez-Flores, MD, PhD, Hospital El Bierzo and Clinica Ponferrada, Spain

Positive stains

● Keratin, EMA, CEA, S100, vimentin

Differential diagnosis

Apocrine mixed tumor
● Metastatic disease (renal cell carcinoma)
● Primary skin tumors with follicular differentiation
● Sebaceous differentiation, or sweat gland differentiation
● Glomus tumor (different staining pattern)

End of Skin - Nonmelanocytic tumors > Adnexal tumors - eccrine sweat glands > Eccrine acrospiroma

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