Skin - Nonmelanocytic tumors
Adnexal tumors - eccrine sweat glands
Eccrine cylindroma

Author: Christopher Hale, M.D. (see Authors page)

Revised: 5 October 2016, last major update June 2012

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PubMed Search: Eccrine cylindroma

Cite this page: Eccrine cylindroma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skintumornonmelanocyticeccrinecylindroma.html. Accessed December 9th, 2016.
Definition / General
  • Also called turban tumor, particularly when a large, multicentric scalp tumor; dermal cylindroma
  • Somewhat common
  • Solitary, small, slow growing adenoma
  • 90% in head and neck
  • Usually ages 40+ years, 90% women
  • Rarely associated with similar tumors in major salivary glands

Familial form (turban tumor syndrome, Brooke-Spiegler syndrome):
  • Autosomal dominant, multiple tumors of children / teenagers that may also involve trunk and extremities, or in association with spiradenoma, trichoepithelioma, milia or membranous variant of basal cell adenoma of salivary glands
  • Due to mutations in CYLD gene at chromosome 16q12-13
  • Rarely undergoes malignant transformation (J Dermatol Case Rep 2007;1:4)

Spiradenocylindromas:
  • Features of cylindroma and eccrine spiradenoma
  • Usually painful
Clinical Images

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Patient with Brooke-Spiegler syndrome

Gross Description
  • Pink-red dome-shaped nodule with smooth surface
Micro Description
  • Compact nests of basaloid cells that fit together like a jigsaw puzzle, surrounded by thick basement membrane
Micro Images

Images hosted on PathOut servers:

Contributed by Mark R. Wick, M.D.



Images hosted on Flickr:

Cylindroma



Images hosted on other servers:

Various images

Molecular / Cytogenetics Description
  • Mutation in CYLD gene in #16 associated with multiple cylindromas
Electron Microscopy Description
  • Differentiation towards intradermal coiled duct region of eccrine sweat glands
Differential Diagnosis