Skin nonmelanocytic tumor
Adnexal tumors
Sweat gland derived (apocrine & eccrine glands)

Topic Completed: 1 June 2012

Minor changes: 31 May 2020

Copyright: 2002-2019,, Inc.

PubMed Search: cylindroma

Christopher S. Hale, M.D.
Page views in 2019: 13,505
Page views in 2020 to date: 8,081
Cite this page: Hale CS. Cylindroma. website. Accessed August 14th, 2020.
Definition / general
  • Also called turban tumor, particularly when a large, multicentric scalp tumor; dermal cylindroma
  • Somewhat common
  • Solitary, small, slow growing adenoma
  • 90% in head and neck
  • Usually ages 40+ years, 90% women
  • Rarely associated with similar tumors in major salivary glands

Familial form (turban tumor syndrome, Brooke-Spiegler syndrome):
  • Autosomal dominant, multiple tumors of children / teenagers that may also involve trunk and extremities, or in association with spiradenoma, trichoepithelioma, milia or membranous variant of basal cell adenoma of salivary glands
  • Due to mutations in CYLD gene at chromosome 16q12-13
  • Rarely undergoes malignant transformation (J Dermatol Case Rep 2007;1:4)

  • Features of cylindroma and eccrine spiradenoma
  • Usually painful
Clinical images

Images hosted on other servers:

Patient with Brooke-Spiegler syndrome

Gross description
  • Pink-red dome-shaped nodule with smooth surface
Microscopic (histologic) description
  • Compact nests of basaloid cells that fit together like a jigsaw puzzle, surrounded by thick basement membrane
Microscopic (histologic) images

Images hosted on PathOut servers:

Contributed by Mark R. Wick, M.D.

Images hosted on Flickr:


Images hosted on other servers:

Various images

Molecular / cytogenetics description
  • Mutation in CYLD gene in #16 associated with multiple cylindromas
Electron microscopy description
  • Differentiation towards intradermal coiled duct region of eccrine sweat glands
Differential diagnosis
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