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Skin - Nonmelanocytic tumors

Other tumors of skin

Epithelial sheath neuroma

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 14 September 2012, last major update September 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.


● Benign proliferation of nerve fibers ensheathed by squamous epithelium involving the superficial dermis (Am J Surg Pathol 2000;24:190)

Case reports

● 49 year old woman with 5 mm solitary, erythematous, pruritic papule on upper back (Am J Dermatopathol 2006;28:216)
● 86 year old man with pruritic pink plaque on upper back (J Cutan Pathol 2012 Aug 9999;9999 [Epub ahead of print])

Micro description

● Increased discrete, enlarged nerve bundles in upper dermis with myxoid perineuroepithelial fibroplasia

Differential diagnosis

● Malignant epithelial neoplasm with perineurial invasion
● Cutaneous nerve hyperplasia: associated with MEN2b syndrome; lacks perineural lymphocytic response

End of Skin - Nonmelanocytic tumors > Other tumors of skin > Epithelial sheath neuroma

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