Skin - Nonmelanocytic tumors
Lymphoma and related disorders
Epithelioid hemangioendothelioma

Author: Christopher Hale, M.D. (see Authors page)

Revised: 12 October 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed search: epithelioid [title] hemangioendothelioma skin

Cite this page: Epithelioid hemangioendothelioma. website. Accessed October 19th, 2018.
Definition / general
  • Superficial and soft tissues in adults; also lung, liver, GI, other sites
  • Arise from endothelial cells
  • Intermediate biology between hemangioma and angiosarcoma
Case reports
Microscopic (histologic) description
  • Well differentiated nests and cords of cells with abundant eosinophilic cytoplasm and prominent intracytoplasmic lumina
Microscopic (histologic) images
Images hosted on other servers:

Various images

Positive stains
Differential diagnosis
  • Angiosarcoma: infiltrating, freely anastomosing channels lined by spindled to epithelioid endothelial cells with marked atypia, surrounding adnexae and dissecting dermal collagen
  • Hemangioma: usually smaller, heavy infiltrate of eosinophils and lymphocytes with germinal centers; usually less atypia
  • Masson tumor: dilated vessel with papillary proliferation of plump endothelial cells without atypia overlying fibrous tissue; fibrin deposition and thrombi present