Skin nonmelanocytic tumor
Lymphoma and related disorders
Epithelioid hemangioendothelioma

Topic Completed: 1 August 2012

Revised: 4 April 2019

Copyright: 2003-2016,, Inc.

PubMed search: epithelioid [title] hemangioendothelioma skin

Christopher S. Hale, M.D.
Page views in 2018: 2,490
Page views in 2019 to date: 2,057
Cite this page: Hale C. Epithelioid hemangioendothelioma. website. Accessed October 20th, 2019.
Definition / general
  • Superficial and soft tissues in adults; also lung, liver, GI, other sites
  • Arise from endothelial cells
  • Intermediate biology between hemangioma and angiosarcoma
Case reports
Microscopic (histologic) description
  • Well differentiated nests and cords of cells with abundant eosinophilic cytoplasm and prominent intracytoplasmic lumina
Microscopic (histologic) images
Images hosted on other servers:

Various images

Positive stains
Differential diagnosis
  • Angiosarcoma: infiltrating, freely anastomosing channels lined by spindled to epithelioid endothelial cells with marked atypia, surrounding adnexae and dissecting dermal collagen
  • Hemangioma: usually smaller, heavy infiltrate of eosinophils and lymphocytes with germinal centers; usually less atypia
  • Masson tumor: dilated vessel with papillary proliferation of plump endothelial cells without atypia overlying fibrous tissue; fibrin deposition and thrombi present
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