Skin nonmelanocytic tumor
Adnexal tumors
Sweat gland derived (apocrine & eccrine glands)
Hidradenoma papilliferum

Topic Completed: 1 June 2012

Minor changes: 4 April 2019

Copyright: 2002-2016,, Inc.

PubMed Search: Hidradenoma papilliferum [title]

Christopher S. Hale, M.D.
Page views in 2019: 14,509
Page views in 2020 to date: 7,183
Cite this page: Hale C. Hidradenoma papilliferum. website. Accessed August 6th, 2020.
Definition / general
  • Also called papillary hidradenoma
  • Most common neoplasm of anogenital mammary-like glands
  • Exclusively in women
  • Perianal or vulvar (similar frequency in labia majora and labia minora)
  • Rare ectopic├╣ cases from eyelid, nasal area, breast
Case reports
  • Slow-growing, firm, reddish nodule, may ulcerate
Clinical images

Images hosted on PathOut servers:

Vulva, courtesy of Mark R. Wick, M.D.

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Lesions on labia majora

Nose lesion

Microscopic (histologic) description
  • Papillary fronds, ducts lined by apocrine type cells that show decapitation secretion and fibrous stroma
Microscopic (histologic) images

Images hosted on PathOut servers:

Case of the Week #343

Courtesy of Dr. Mark R. Wick:

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Lesion on labia majora

Lesion on nose

Cytology description
  • Monomorphic population of cohesive cells with uniform pale staining nuclear chromatin, orderly nuclear placement, and round globules of metachromatic staining hyalinized material (Diagn Cytopathol 1994;10:60)
Negative stains
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