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Skin - Nonmelanocytic tumors

Adnexal tumors - apocrine glands

Hidradenoma papilliferum


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 2 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Also called papillary hidradenoma
● Most common neoplasm of anogenital mammary-like glands
● Exclusively in women
● Perianal or vulvar (similar frequency in labia majora and labia minora)
● Rare “ectopic” cases from eyelid, nasal area, breast

Case reports
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● 35 year old woman with asymptomatic lesion on labia majora (Indian J Dermatol Venereol Leprol 2009;75:327)
● 43 year old female with nasal (non-anogenital / ectopic) tumor (Ann Dermatol 2011;23:S254)

Gross description
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● Slow-growing, firm, reddish nodule, may ulcerate

Gross images
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Lesions on labia majora and nose

Micro description
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● Papillary fronds, ducts lined by apocrine type cells that show decapitation secretion and fibrous stroma

Micro images
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Lesion on labia majora

           
Lesion on nose

Cytology
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● Monomorphic population of cohesive cells with uniform pale staining nuclear chromatin, orderly nuclear placement, and round globules of metachromatic staining hyalinized material (Diagn Cytopathol 1994;10:60)

Positive stains
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● AE1/AE3, CK5/6, GCDFP-15, androgen receptor, ER (Adv Anat Pathol 2011;18:1)

Negative stains
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● S100, HMWK

Differential diagnosis
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● Syringocystadenoma papilliferum
● Tubular apocrine adenoma

End of Skin - Nonmelanocytic tumors > Adnexal tumors - apocrine glands > Hidradenoma papilliferum


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