Home   Chapter Home   Jobs   Conferences   Fellowships   Books

Advertisement

Skin - Nonmelanocytic tumors

Adnexal tumors - apocrine glands

Hidradenoma papilliferum

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 2 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Also called papillary hidradenoma
● Most common neoplasm of anogenital mammary-like glands
● Exclusively in women
● Perianal or vulvar (similar frequency in labia majora and labia minora)
● Rare “ectopic” cases from eyelid, nasal area, breast

Case reports
=========================================================================

● 35 year old woman with asymptomatic lesion on labia majora (Indian J Dermatol Venereol Leprol 2009;75:327)
● 43 year old female with nasal (non-anogenital / ectopic) tumor (Ann Dermatol 2011;23:S254)

Gross description
=========================================================================

● Slow-growing, firm, reddish nodule, may ulcerate

Gross images
=========================================================================

   
Lesions on labia majora and nose

Micro description
=========================================================================

● Papillary fronds, ducts lined by apocrine type cells that show decapitation secretion and fibrous stroma

Micro images
=========================================================================

       
Lesion on labia majora

           
Lesion on nose

Cytology
=========================================================================

● Monomorphic population of cohesive cells with uniform pale staining nuclear chromatin, orderly nuclear placement, and round globules of metachromatic staining hyalinized material (Diagn Cytopathol 1994;10:60)

Positive stains
=========================================================================

● AE1/AE3, CK5/6, GCDFP-15, androgen receptor, ER (Adv Anat Pathol 2011;18:1)

Negative stains
=========================================================================

● S100, HMWK

Differential diagnosis
=========================================================================

● Syringocystadenoma papilliferum
● Tubular apocrine adenoma

End of Skin - Nonmelanocytic tumors > Adnexal tumors - apocrine glands > Hidradenoma papilliferum

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).