Skin - Nonmelanocytic tumors
Other tumors of skin

Author: Christopher Hale, M.D. (see Authors page)

Revised: 4 October 2016, last major update September 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Histiocytoma [title] skin

Related topics: Solitary epithelioid, Generalized eruptive

Cite this page: Histiocytoma. website. Accessed October 23rd, 2016.
Definition / General
  • Tumor of true histiocytic origin, not fibrohistiocytic
  • By definition, excludes Langerhans cell histiocytosis
  • Occurs in children; most tumors are benign
Micro Description
  • Closely packed histiocytes with eosinophilic cytoplasm and variable lipid droplets, often inflammatory cells
  • Minimal stroma
  • Older lesions have fibrosis but no active fibroblastic proliferation
Positive Stains
Negative Stains
Electron Microscopy Description
  • No Birbeck granules