Home   Chapter Home   Jobs   Conferences   Fellowships   Books

Advertisement

Skin - Nonmelanocytic tumors

Other tumors of skin

Histiocytoma

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 14 September 2012, last major update September 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Tumor of true histiocytic origin, not fibrohistiocytic
● By definition, excludes Langerhans cell histiocytosis
● Occurs in children; most tumors are benign

Micro description
=========================================================================

● Closely packed histiocytes with eosinophilic cytoplasm and variable lipid droplets, often inflammatory cells
● Minimal stroma
● Older lesions have fibrosis but no active fibroblastic proliferation

Positive stains
=========================================================================

● CD68

Negative stains
=========================================================================

● S100, CD45, CD1a

Electron microscopy description
=========================================================================

● No Birbeck granules

Solitary epithelioid histiocytoma

General
=========================================================================

● Solitary or multifocal tumor, often with articular involvement (Am J Surg Pathol 2006;30:521)
● Formerly called reticulohistiocytoma
● May have malignant behavior

Case reports
=========================================================================

● 39 year old woman with eyelid lesion (Arch Ophthalmol 2011;129:1502)

Micro description
=========================================================================

● Usually upper dermis
● Mononuclear and multinuclear epithelioid histiocytes with eosinophilic to glassy cytoplasm, often with spike-like cytoplasmic extensions
● Nuclei are round/oval with distinct nucleoli and variable nuclear grooves and multinucleation
● Frequent lymphocytes and neutrophils

Micro images
=========================================================================

Dermis contains multinucleated forms


Dermal tumor contains mild atypia, and pushes against epidermis

Giant cell reticulohistiocytoma #1, Giant cell reticulohistiocytoma #2, Giant cell reticulohistiocytoma #3

Positive stains
=========================================================================

● Vimentin, CD163, Factor XIIIa (focal), CD68 (may be focal)

Negative stains
=========================================================================

● S100, keratin, MelanA

Generalized eruptive histiocytoma

General
=========================================================================

● Benign, papular, self-healing histiocytosis characterized by recurrent crops of small, firm, tan to red papules that appear in a symmetrical fashion on the face, trunk and arms, and may regress spontaneously
● Rare, <50 cases described, most in adults
● Part of spectrum of non-Langerhans cell histiocytosis

Case reports
=========================================================================

● 32 year old woman successfully treated with PUVA (J Dtsch Dermatol Ges 2007;5:131)
● 49 year old woman with multiple papules (J Dermatol Case Rep 2011;5:53)

Treatment
=========================================================================

● Local excision - excellent prognosis

Clinical images
=========================================================================

Various images

Micro images
=========================================================================

Various images

Positive stains
=========================================================================

● CD68, MAC387, alpha-1-antichymotrypsin, lysozyme

Negative stains
=========================================================================

● S100, CD1a

Electron microscopy description
=========================================================================

● No Birbeck granules

End of Skin - Nonmelanocytic tumors > Other tumors of skin > Histiocytoma

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).