Skin - Nonmelanocytic tumors
Other tumors of skin

Author: Christopher Hale, M.D. (see Authors page)

Revised: 4 October 2016, last major update September 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Histiocytoma [title] skin

Related topics: Solitary epithelioid, Generalized eruptive

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Cite this page: Histiocytoma. website. Accessed March 19th, 2019.
Definition / general
  • Tumor of true histiocytic origin, not fibrohistiocytic
  • By definition, excludes Langerhans cell histiocytosis
  • Occurs in children; most tumors are benign
Microscopic (histologic) description
  • Closely packed histiocytes with eosinophilic cytoplasm and variable lipid droplets, often inflammatory cells
  • Minimal stroma
  • Older lesions have fibrosis but no active fibroblastic proliferation
Positive stains
Negative stains
Electron microscopy description
  • No Birbeck granules
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