Skin - Nonmelanocytic tumors
Vascular tumors
Intravascular papillary endothelial hyperplasia

Author: Christopher Hale, M.D. (see Authors page)

Revised: 6 October 2016, last major update July 2012

Copyright: (c) 2001-2016,, Inc.

PubMed search: intravascular papillary endothelial [title] hyperplasia

Related topic: Soft tissue chapter

Cite this page: Intravascular papillary endothelial hyperplasia. website. Accessed October 25th, 2016.
Definition / General
  • Also called Masson hemangioma (Am J Dermatopathol 2003;25:71)
  • Often on fingers and in hemorrhoids
  • In skin, associated with preexisting pyogenic granuloma or hemangioma, vascular malformations or hemangiomas of blue rubber bleb nevus syndrome
  • Due to exuberant recanalization of a thrombus
  • May be secondary to trauma or superimposed on pyogenic granuloma or cavernous hemangioma
  • Slow growing, tender, blue red, deep dermal to subcutaneous mass
  • Rarely recurs after excision
Case Reports
Micro Description
  • Dilated vessel contains papillary proliferation of plump endothelial cells without atypia overlying fibrous tissue
  • Fibrin deposition and thrombi present
  • Variable pleomorphism and stratification, no/rare mitotic figures, no necrosis, no solid cellular areas
Micro Images
Images hosted on other servers:

Various images

Differential Diagnosis
  • Angiosarcoma: infiltrating, freely anastomosing channels lined by spindled to epithelioid endothelial cells with marked atypia, surrounding adnexae and dissecting dermal collagen