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Skin - Nonmelanocytic tumors

Vascular tumors

Intravascular papillary endothelial hyperplasia


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 7 November 2014, last major update August 2012
Copyright: (c) 2001-2014, PathologyOutlines.com, Inc.

See also Soft tissue chapter

General
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● Also called Masson hemangioma (Am J Dermatopathol 2003;25:71)
● Often on fingers and in hemorrhoids
● In skin, associated with preexisting pyogenic granuloma or hemangioma, vascular malformations or hemangiomas of blue rubber bleb nevus syndrome
● Due to exuberant recanalization of a thrombus
● May be secondary to trauma or superimposed on pyogenic granuloma or cavernous hemangioma
● Slow growing, tender, blue-red, deep dermal to subcutaneous mass
● Rarely recurs after excision

Case reports
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● 70 year old woman with 1 cm lesion on buccal mucosa (Case Rep Dermatol 2010 2;1:22)

Micro description
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● Dilated vessel contains papillary proliferation of plump endothelial cells without atypia overlying fibrous tissue
● Fibrin deposition and thrombi present
● Variable pleomorphism and stratification, no/rare mitotic figures, no necrosis, no solid cellular areas

Micro images
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Various images

Differential diagnosis
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Angiosarcoma: infiltrating, freely anastomosing channels lined by spindled to epithelioid endothelial cells with marked atypia, surrounding adnexae and dissecting dermal collagen

End of Skin - Nonmelanocytic tumors > Vascular tumors > Intravascular papillary endothelial hyperplasia


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