Skin - Nonmelanocytic tumors
Intravascular papillary endothelial hyperplasia
Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 7 November 2014, last major update August 2012
Copyright: (c) 2001-2014, PathologyOutlines.com, Inc.
See also Soft tissue chapter
● Also called Masson hemangioma (Am J Dermatopathol 2003;25:71)
● Often on fingers and in hemorrhoids
● In skin, associated with preexisting pyogenic granuloma or hemangioma, vascular malformations or hemangiomas of blue rubber bleb nevus syndrome
● Due to exuberant recanalization of a thrombus
● May be secondary to trauma or superimposed on pyogenic granuloma or cavernous hemangioma
● Slow growing, tender, blue-red, deep dermal to subcutaneous mass
● Rarely recurs after excision
● 70 year old woman with 1 cm lesion on buccal mucosa
(Case Rep Dermatol 2010 2;1:22)
● Dilated vessel contains papillary proliferation of plump endothelial cells without atypia overlying fibrous tissue
● Fibrin deposition and thrombi present
● Variable pleomorphism and stratification, no/rare mitotic figures, no necrosis, no solid cellular areas
● Angiosarcoma: infiltrating, freely anastomosing channels lined by spindled to epithelioid endothelial cells with marked atypia, surrounding adnexae and dissecting dermal collagen
End of Skin - Nonmelanocytic tumors > Vascular tumors > Intravascular papillary endothelial hyperplasia
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