Home   Chapter Home   Jobs   Conferences   Fellowships   Books


Skin - Nonmelanocytic tumors

Vascular tumors

Intravascular papillary endothelial hyperplasia

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 7 November 2014, last major update August 2012
Copyright: (c) 2001-2014, PathologyOutlines.com, Inc.

See also Soft tissue chapter


● Also called Masson hemangioma (Am J Dermatopathol 2003;25:71)
● Often on fingers and in hemorrhoids
● In skin, associated with preexisting pyogenic granuloma or hemangioma, vascular malformations or hemangiomas of blue rubber bleb nevus syndrome
● Due to exuberant recanalization of a thrombus
● May be secondary to trauma or superimposed on pyogenic granuloma or cavernous hemangioma
● Slow growing, tender, blue-red, deep dermal to subcutaneous mass
● Rarely recurs after excision

Case reports

● 70 year old woman with 1 cm lesion on buccal mucosa (Case Rep Dermatol 2010 2;1:22)

Micro description

● Dilated vessel contains papillary proliferation of plump endothelial cells without atypia overlying fibrous tissue
● Fibrin deposition and thrombi present
● Variable pleomorphism and stratification, no/rare mitotic figures, no necrosis, no solid cellular areas

Micro images

Various images

Differential diagnosis

Angiosarcoma: infiltrating, freely anastomosing channels lined by spindled to epithelioid endothelial cells with marked atypia, surrounding adnexae and dissecting dermal collagen

End of Skin - Nonmelanocytic tumors > Vascular tumors > Intravascular papillary endothelial hyperplasia

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at [email protected] with any questions (click here for other contact information).