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Skin - Nonmelanocytic tumors

Other tumors of skin

Keloid

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 14 September 2012, last major update September 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Abnormal fibroblast reaction to injury
● Usually in people of African descent, often in earlobe
● High rate of recurrence after excision

Treatment
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● Corticosteroid injection

Micro description
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● Wide bands of collagen with large, brightly eosinophilic, glassy fibers
● Also parallel fibroblasts and myofibroblasts
● Mucinous pools after steroid injection

Molecular description
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● Epigenetic alteration in fibroblast DNA and acetylation of histone proteins (J Invest Dermatol 2010;130:2489)

Differential diagnosis
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● Hyperplastic scar
● Keloidal dermatofibroma
● Complication of acne

End of Skin - Nonmelanocytic tumors > Other tumors of skin > Keloid

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