Skin - Nonmelanocytic tumors
Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 19 August 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.
● Rare chronic inflammatory disorder of deep subcutaneous tissue, etiology unknown (Arch Pathol Lab Med 2007;131:650)
● Usually head and neck, often associated with regional lymphadenopathy or salivary gland involvement
● Usually affects Asian males, but similar presentation in US (Am J Surg Pathol 2004;28:505)
● Almost always affects nodal sites; often associated dermal involvement
● Usually peripheral blood eosinophilia and elevated serum IgE
● Benign and reactive
● May recur, no/rare death from disease
● 5 year old boy with asymptomatic solitary brown pigmented nodule on left buttock
(Ann Dermatol 2010;22:57)
Lesion on buttock
● Large tumor-like lesions
● Lymph nodes have preserved architecture, but also follicular hyperplasia, prominent eosinophilic infiltrates, proliferation of postcapillary venules
● Marked fibrosis in advanced stage disease
● Angiolymphoid hyperplasia with eosinophilia / epithelioid hemangioma
● Hypersensitivity or drug reactions
End of Skin - Nonmelanocytic tumors > Vascular tumors > Kimura’s disease
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