Skin nonmelanocytic tumor
Vascular tumors
Kimura's disease

Topic Completed: 1 July 2015

Revised: 4 April 2019

Copyright: 2003-2016,, Inc.

PubMed search: Kimura's disease [title] skin

Christopher S. Hale, M.D.
Page views in 2018: 1,077
Page views in 2019 to date: 797
Cite this page: Hale C. Kimuras disease. website. Accessed July 20th, 2019.
Definition / general
  • Rare chronic inflammatory disorder of deep subcutaneous tissue, etiology unknown (Arch Pathol Lab Med 2007;131:650)
  • Usually head and neck, often associated with regional lymphadenopathy or salivary gland involvement
  • Usually affects Asian males, but similar presentation in US (Am J Surg Pathol 2004;28:505)
  • Almost always affects nodal sites; often associated dermal involvement
  • Usually peripheral blood eosinophilia and elevated serum IgE
  • Benign and reactive
  • May recur, no / rare death from disease
Case reports
Clinical images
Images hosted on other servers:

Lesion on buttock

Gross description
  • Large tumor-like lesions
Microscopic (histologic) description
  • Lymph nodes have preserved architecture, but also follicular hyperplasia, prominent eosinophilic infiltrates, proliferation of postcapillary venules
  • Marked fibrosis in advanced stage disease
Microscopic (histologic) images
Images hosted on PathOut server:

Courtesy of Dr. Mark R. Wick

Images hosted on other servers:

Various images

Preserved nodal architecture

Differential diagnosis
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