Skin - Nonmelanocytic tumors
Vascular tumors
Kimura's disease

Author: Christopher Hale, M.D. (see Authors page)

Revised: 7 October 2016, last major update July 2015

Copyright: (c) 2003-2016,, Inc.

PubMed search: Kimura's disease [title] skin

Cite this page: Kimuras disease. website. Accessed November 20th, 2018.
Definition / general
  • Rare chronic inflammatory disorder of deep subcutaneous tissue, etiology unknown (Arch Pathol Lab Med 2007;131:650)
  • Usually head and neck, often associated with regional lymphadenopathy or salivary gland involvement
  • Usually affects Asian males, but similar presentation in US (Am J Surg Pathol 2004;28:505)
  • Almost always affects nodal sites; often associated dermal involvement
  • Usually peripheral blood eosinophilia and elevated serum IgE
  • Benign and reactive
  • May recur, no / rare death from disease
Case reports
Clinical images
Images hosted on other servers:

Lesion on buttock

Gross description
  • Large tumor-like lesions
Microscopic (histologic) description
  • Lymph nodes have preserved architecture, but also follicular hyperplasia, prominent eosinophilic infiltrates, proliferation of postcapillary venules
  • Marked fibrosis in advanced stage disease
Microscopic (histologic) images
Images hosted on PathOut server:

Courtesy of Dr. Mark R. Wick

Images hosted on other servers:

Various images

Preserved nodal architecture

Differential diagnosis