Skin tumor - Nonmelanocytic - Kimura’s disease

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Skin - Nonmelanocytic tumors

Vascular tumors

Kimura’s disease

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 19 August 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Rare chronic inflammatory disorder of deep subcutaneous tissue, etiology unknown (Arch Pathol Lab Med 2007;131:650)
● Usually head and neck, often associated with regional lymphadenopathy or salivary gland involvement
● Usually affects Asian males, but similar presentation in US (Am J Surg Pathol 2004;28:505)
● Almost always affects nodal sites; often associated dermal involvement
● Usually peripheral blood eosinophilia and elevated serum IgE
● Benign and reactive
● May recur, no/rare death from disease

Case reports
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● 5 year old boy with asymptomatic solitary brown pigmented nodule on left buttock (Ann Dermatol 2010;22:57)

Clinical images
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Lesion on buttock

Gross description
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● Large tumor-like lesions

Micro description
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● Lymph nodes have preserved architecture, but also follicular hyperplasia, prominent eosinophilic infiltrates, proliferation of postcapillary venules
● Marked fibrosis in advanced stage disease

Micro images
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Various images

Differential diagnosis
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● Angiolymphoid hyperplasia with eosinophilia / epithelioid hemangioma
● Hypersensitivity or drug reactions
● Infections

End of Skin - Nonmelanocytic tumors > Vascular tumors > Kimura’s disease

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