Skin tumor - Nonmelanocytic - Large cell acanthoma

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Skin - Nonmelanocytic tumors

Benign nonmelanotic epidermal tumors / tumor-like lesions

Large cell acanthoma

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 25 June 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Sun exposed skin, usually cheek or forehead
● Benign, although may be related to actinic keratosis

Case reports
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● 62 year old man with multiple acanthomas (J Am Acad Dermatol 2005;53:335)

Gross description
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● Light-tan to dark brown macule

Micro description
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● Atrophic, acanthotic or verrucous epidermis
● Hyperpigmented basal layer with rounded contour of rete ridges
● Larger than usual keratinocytes (large nuclei and cytoplasm) compared to adjacent normal epidermis
● No atypia

Micro images
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Large keratinocytes, hyperkeratosis

Differential diagnosis
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● Actinic keratosis
● Solar lentigo
● Bowen’s disease

End of Skin - Nonmelanocytic tumors > Benign nonmelanotic epidermal tumors / tumor-like lesions > Large cell acanthoma

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