Skin - Nonmelanocytic tumors
Benign nonmelanotic epidermal tumors / tumor-like lesions
Large cell acanthoma
Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 25 June 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.
● Sun exposed skin, usually cheek or forehead
● Benign, although may be related to actinic keratosis
● 62 year old man with multiple acanthomas
(J Am Acad Dermatol 2005;53:335)
● Light-tan to dark brown macule
● Atrophic, acanthotic or verrucous epidermis
● Hyperpigmented basal layer with rounded contour of rete ridges
● Larger than usual keratinocytes (large nuclei and cytoplasm) compared to adjacent normal epidermis
● No atypia
Large keratinocytes, hyperkeratosis
● Actinic keratosis
● Solar lentigo
● Bowen’s disease
End of Skin - Nonmelanocytic tumors > Benign nonmelanotic epidermal tumors / tumor-like lesions > Large cell acanthoma
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