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Skin - Nonmelanocytic tumors

Other tumors of skin


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 14 September 2012, last major update September 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.


● Divided into lesions of nipple or scrotum, pilar leiomyoma or solitary angioleiomyoma (vascular leiomyoma) usually in subcutis
● May be very painful

Familial cutaneous leiomyomatosis (Reed syndrome):
● Due to mutation in fumarate hydratase, may be associated with renal cell carcinoma (Dermatol Online J 2005;11:21)

Micro description

● Intersecting smooth muscle fascicles
● May have scattered bizarre hyperchromatic nuclei (symplastic leiomyoma)
● No atypia, no mitotic activity, no necrosis

Pilar leiomyoma:
● Dermal intersecting fascicles of eosinophilic spindle cells with plump, cigar-shaped nuclei with dermal collagen bundles

Micro images

Various images - contributed by Angel Fernandez-Flores, MD, PhD, Hospital El Bierzo and Clinica Ponferrada, Spain

Positive stains

● Desmin, variable keratin and EMA

Negative stains

● S100, GFAP

Differential diagnosis

● Myoepithelioma: desmin-, S100+

End of Skin - Nonmelanocytic tumors > Other tumors of skin > Leiomyoma

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