Skin - Nonmelanocytic tumors
Other tumors of skin

Author: Christopher Hale, M.D. (see Authors page)

Revised: 5 October 2016, last major update September 2012

Copyright: (c) 2001-2016,, Inc.

PubMed search: leiomyoma [title] skin

Cite this page: Leiomyoma. website. Accessed September 25th, 2018.
Definition / general
  • Divided into lesions of nipple or scrotum, pilar leiomyoma or solitary angioleiomyoma (vascular leiomyoma) usually in subcutis
  • May be very painful

Familial cutaneous leiomyomatosis (Reed syndrome):
Microscopic (histologic) description
  • Intersecting smooth muscle fascicles
  • May have scattered bizarre hyperchromatic nuclei (symplastic leiomyoma)
  • No atypia, no mitotic activity, no necrosis

Pilar leiomyoma:
  • Dermal intersecting fascicles of eosinophilic spindle cells with plump, cigar shaped nuclei with dermal collagen bundles
Microscopic (histologic) images
Images hosted on PathOut server:

Courtesy of Dr. Angel Fernandez-Flores, M.D., Ph.D, Hospital El Bierzo and Clinica Ponferrada, Spain:

Various images

Positive stains
Negative stains
Differential diagnosis