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Skin - Nonmelanocytic tumors

Other tumors of skin

Leiomyoma


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 14 September 2012, last major update September 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Divided into lesions of nipple or scrotum, pilar leiomyoma or solitary angioleiomyoma (vascular leiomyoma) usually in subcutis
● May be very painful

Familial cutaneous leiomyomatosis (Reed syndrome):
● Due to mutation in fumarate hydratase, may be associated with renal cell carcinoma (Dermatol Online J 2005;11:21)

Micro description
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● Intersecting smooth muscle fascicles
● May have scattered bizarre hyperchromatic nuclei (symplastic leiomyoma)
● No atypia, no mitotic activity, no necrosis

Pilar leiomyoma:
● Dermal intersecting fascicles of eosinophilic spindle cells with plump, cigar-shaped nuclei with dermal collagen bundles

Micro images
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Various images - contributed by Angel Fernandez-Flores, MD, PhD, Hospital El Bierzo and Clinica Ponferrada, Spain

Positive stains
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● Desmin, variable keratin and EMA

Negative stains
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● S100, GFAP

Differential diagnosis
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● Myoepithelioma: desmin-, S100+

End of Skin - Nonmelanocytic tumors > Other tumors of skin > Leiomyoma


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