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Skin - Nonmelanocytic tumors

Lymphoma and related disorders

Lymphoid hyperplasia


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 15 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Nonspecific finding
● May be due to trauma, infection, arthropods

Treatment
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● Rituximab may be useful (Clin Lymphoma Myeloma Leuk 2011;11:286)

Gross description
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● Solitary nodules or plaques

Micro description
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● Lymphocytic and histiocytic infiltrate with tingible body macrophages, plasma cells, eosinophils
● Often germinal cells or lymphoid follicles, hyperplastic vessels or epidermal hyperplasia
● Usually spares epidermis

Micro images
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Various images

Positive stains
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● Both kappa and lambda light chain expression, both B and T cells

Differential diagnosis
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● MALT lymphoma: marginal zone cells, Dutcher bodies, sheets of plasma cells

End of Skin - Nonmelanocytic tumors > Lymphoma and related disorders > Lymphoid hyperplasia


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