Skin nonmelanocytic tumor
Lymphoma and related disorders
Lymphoid hyperplasia

Topic Completed: 1 June 2012

Minor changes: 4 April 2019

Copyright: 2003-2016,, Inc.

PubMed search: Lymphoid hyperplasia [title]

Christopher S. Hale, M.D.
Page views in 2019: 3,987
Page views in 2020 to date: 2,028
Cite this page: Hale C. Lymphoid hyperplasia. website. Accessed July 13th, 2020.
Definition / general
  • Nonspecific finding
  • May be due to trauma, infection, arthropods
Clinical images
Images hosted on PathOut server:

Breast skin, courtesy of Dr. Mark R. Wick

Gross description
  • Solitary nodules or plaques
Microscopic (histologic) description
  • Lymphocytic and histiocytic infiltrate with tingible body macrophages, plasma cells, eosinophils
  • Often germinal cells or lymphoid follicles, hyperplastic vessels or epidermal hyperplasia
  • Usually spares epidermis
Microscopic (histologic) images
Images hosted on PathOut server:

Breast skin

Various images

Florid idiopathic


Images hosted on other servers:

Various images

Positive stains
  • Both kappa and lambda light chain expression, both B and T cells
Differential diagnosis
  • MALT lymphoma: marginal zone cells, Dutcher bodies, sheets of plasma cells
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