Skin - Nonmelanocytic tumors
Lymphoma and related disorders
Lymphomatoid papulosis

Author: Christopher Hale, M.D. (see Authors page)

Revised: 11 October 2016, last major update June 2012

Copyright: (c) 2003-2016,, Inc.

PubMed search: Lymphomatoid papulosis [title] skin

Cite this page: Lymphomatoid papulosis. website. Accessed October 28th, 2016.
Definition / General
  • Rare, self healing, recurrent papular eruption
  • Indolent clinical course, although 10% are associated with or evolve to anaplastic large cell lymphoma
  • May be self healing "benign" phase of anaplastic large cell lymphoma (per Rosai)
  • May resemble pityriasis lichenoides et varioliformis acuta, or have large ulcerated plaques and nodules
Case Reports
  • Regular followup
Clinical Images
Images hosted on PathOut server:

Courtesy of Dr. Mark R. Wick

Images hosted on other servers:

Erythematous nodule on forearm

Micro Description
  • Wedge shaped on low power with base of lymphocytes at epidermis and tip deep within reticular dermis
  • Polymorphic superficial dermal infiltrate, usually perivascular, with thin epidermis
  • Occasional atypical lymphoid cells resembling Reed-Sternberg cells or "lumps of coal"
  • Often obscures dermoepidermal junction with variable epidermotropism
  • Type A:
    • Pleomorphic CD30+ lymphocytes with hyperchromatic nuclei that may mimic Reed-Sternberg cells
    • Also mixed inflammatory infiltrate
  • Type B:
    • Relatively small hyperchromatic lymphocytes with complex nuclear membranes
Micro Images
Images hosted on PathOut server:

Type A, courtesy of Angel Fernandez-Flores, M.D., Ph.D., Hospital El Bierzo and Clinica Ponferrada, Spain


Courtesy of Dr. Mark R. Wick

Molecular / Cytogenetics Description
  • T cells are clonal, but this doesn't predict transformation to lymphoma
Differential Diagnosis
Additional References