Skin nonmelanocytic tumor
Lymphoma and related disorders - T cell / NK cell neoplasms
Lymphomatoid papulosis

Topic Completed: 1 June 2012

Revised: 19 December 2019

Copyright: 2003-2019,, Inc.

PubMed search: Lymphomatoid papulosis [title] skin

Christopher S. Hale, M.D.
Page views in 2019: 5,024
Page views in 2020 to date: 775
Cite this page: Hale CS. Lymphomatoid papulosis. website. Accessed February 27th, 2020.
Definition / general
  • Rare, self healing, recurrent papular eruption
  • Indolent clinical course, although 10% are associated with or evolve to anaplastic large cell lymphoma
  • May be self healing "benign" phase of anaplastic large cell lymphoma (per Rosai)
  • May resemble pityriasis lichenoides et varioliformis acuta, or have large ulcerated plaques and nodules
Case reports
  • Regular followup
Clinical images

Contributed by Mark R. Wick, M.D.

Images hosted on other servers:

Erythematous nodule on forearm

Microscopic (histologic) description
  • Wedge shaped on low power with base of lymphocytes at epidermis and tip deep within reticular dermis
  • Polymorphic superficial dermal infiltrate, usually perivascular, with thin epidermis
  • Occasional atypical lymphoid cells resembling Reed-Sternberg cells or "lumps of coal"
  • Often obscures dermoepidermal junction with variable epidermotropism
  • Type A:
    • Pleomorphic CD30+ lymphocytes with hyperchromatic nuclei that may mimic Reed-Sternberg cells
    • Also mixed inflammatory infiltrate
  • Type B:
    • Relatively small hyperchromatic lymphocytes with complex nuclear membranes
Microscopic (histologic) images

Contributed by Angel Fernandez-Flores, M.D., Ph.D.

Type A


Contributed by Mark R. Wick, M.D.
Molecular / cytogenetics description
  • T cells are clonal, but this doesn't predict transformation to lymphoma
Differential diagnosis
Additional references
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