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Skin - Nonmelanocytic tumors

Lymphoma and related disorders

Mantle zone lymphoma


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 15 July 2012, last major update July 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Chronic and protracted clinical course

Case reports
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● 77 year old man with diffuse erythematous nodules and plaques (Acta Derm Venereol 2011;91:474)

Clinical images
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(a) Diffuse erythematous nodules and plaques involving the back
(b) Large erythematous plaque with erosions and crusts on the gluteal area


Micro description
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● Extensive nodules in reticular dermis and subcutis of small lymphocytes with irregular nuclear membranes and clumped chromatin
● Forms wide mantle zones around germinal centers

Micro images
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Various images

Positive stains
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● Cyclin D1, BCL2, CD5, CD20, CD22, CD79a

Negative stains
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● CD2, CD3, CD4, CD7, CD8, CD10, CD23, TiA1

Additional references
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Ann Oncol 1996;7:S35

End of Skin - Nonmelanocytic tumors > Lymphoma and related disorders > Mantle zone lymphoma


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