Skin tumor - Nonmelanocytic - Mast cell disorders

Home Chapter Home Jobs Conferences Fellowships Books

Skin - Nonmelanocytic tumors

Lymphoma and related disorders

Mast cell disorders

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 15 July 2012, last major update July 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Most cutaneous mast cell disorders have a good prognosis
● Mastocytosis: monomorphic population of mast cells with rare eosinophils
● Telangiectasia macularis eruptive perstans (TMEP): telangiectatic light or dark brown macules
● Urticaria pigmentosa: common form of mastocytosis, numerous small yellow-brown papules, become hives when rubbed

Case reports
=========================================================================

● 53 year old man with erythematous macules and telangiectasia on arm (J Clin Aesthet Dermatol 2011;4:52)

Clinical images
=========================================================================

Small erythematous macules with telangiectasia in arm

Telangiectatic macules in scapular area

Micro description
=========================================================================

● Variable dermal mast cell infiltration
● Variable eosinophils

Micro images
=========================================================================

Various images

Positive stains
=========================================================================

● Toluidine blue and Giemsa demonstrate metachromasia (granules are purple-red)
● Leder chloroacetate esterase, CD117/c-kit

Differential diagnosis
=========================================================================

● Normal skin or dermatoses: must search to find mast cells even with special stains

End of Skin - Nonmelanocytic tumors > Lymphoma and related disorders > Mast cell disorders

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).