Skin nonmelanocytic tumor
Lymphoma and related disorders - other
Cutaneous mastocytosis


Topic Completed: 1 July 2012

Revised: 12 April 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed search: Mast cell disorders [title] skin
Page views in 2018: 887
Page views in 2019 to date: 381
Cite this page: Hale CS. Cutaneous mastocytosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skintumornonmelanocyticmastcell.html. Accessed April 18th, 2019.
Definition / general
  • Most cutaneous mast cell disorders have a good prognosis
  • Mastocytosis: monomorphic population of mast cells with rare eosinophils
  • Telangiectasia macularis eruptive perstans (TMEP): telangiectatic light or dark brown macules
  • Urticaria pigmentosa: common form of mastocytosis, numerous small yellow brown papules, become hives when rubbed
Case reports
Clinical images

Contributed by Mark R. Wick, M.D.

Breast skin



Images hosted on other servers:

Erythematous macules with telangiectasia

Telangiectatic macules in the scapular area

Microscopic (histologic) description
  • Variable dermal mast cell infiltration
  • Variable eosinophils
Microscopic (histologic) images

Contributed by Mark R. Wick, M.D.

Breast skin



Images hosted on other servers:

H & E, sparse mononuclear infiltrate

H & E, mast cells around the prominent capillaries

Giemsa, perivascular mast cells

Positive stains
Differential diagnosis
  • Normal skin or dermatoses: must search to find mast cells even with special stains
Back to top