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Skin - Nonmelanocytic tumors

Lymphoma and related disorders

Mast cell disorders


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 15 July 2012, last major update July 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Most cutaneous mast cell disorders have a good prognosis
Mastocytosis: monomorphic population of mast cells with rare eosinophils
Telangiectasia macularis eruptive perstans (TMEP): telangiectatic light or dark brown macules
Urticaria pigmentosa: common form of mastocytosis, numerous small yellow-brown papules, become hives when rubbed

Case reports
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● 53 year old man with erythematous macules and telangiectasia on arm (J Clin Aesthet Dermatol 2011;4:52)

Clinical images
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Small erythematous macules with telangiectasia in arm


Telangiectatic macules in scapular area

Micro description
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● Variable dermal mast cell infiltration
● Variable eosinophils

Micro images
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Various images

Positive stains
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● Toluidine blue and Giemsa demonstrate metachromasia (granules are purple-red)
● Leder chloroacetate esterase, CD117/c-kit

Differential diagnosis
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● Normal skin or dermatoses: must search to find mast cells even with special stains

End of Skin - Nonmelanocytic tumors > Lymphoma and related disorders > Mast cell disorders


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