Skin - Nonmelanocytic tumors
Lymphoma and related disorders
Mast cell disorders

Author: Christopher Hale, M.D. (see Authors page)

Revised: 10 October 2016, last major update July 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: Mast cell disorders [title] skin

Cite this page: Mast cell disorders. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skintumornonmelanocyticmastcell.html. Accessed December 3rd, 2016.
Definition / General
  • Most cutaneous mast cell disorders have a good prognosis
  • Mastocytosis: monomorphic population of mast cells with rare eosinophils
  • Telangiectasia macularis eruptive perstans (TMEP): telangiectatic light or dark brown macules
  • Urticaria pigmentosa: common form of mastocytosis, numerous small yellow brown papules, become hives when rubbed
Case Reports
Clinical Images
Images hosted on PathOut server:

Breast skin, courtesy of Dr. Mark R. Wick



Images hosted on other servers:

Erythematous macules with telangiectasia

Telangiectatic macules in the scapular area

Micro Description
  • Variable dermal mast cell infiltration
  • Variable eosinophils
Micro Images
Images hosted on PathOut server:

Breast skin, courtesy of Dr. Mark R. Wick



Images hosted on other servers:

H & E, sparse mononuclear infiltrate

H & E, mast cells around the prominent capillaries

Giemsa, perivascular mast cells

Positive Stains
Differential Diagnosis
  • Normal skin or dermatoses: must search to find mast cells even with special stains