Skin - Nonmelanocytic tumors
Benign nonmelanotic epidermal tumors / tumor-like lesions
Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 25 June 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.
● May be a pigmented variant of seborrheic keratosis
● Benign; cutaneous and oral variants, also called “melanoepithelioma”
● 65 year old man with “giant variant” melanoacanthoma
(Indian J Dermatol 2011;56:79)
● Pigmented plaque, papule or nodule
● Dull surface
● Resembles seborrheic keratosis but with prominent, dendritic melanocytes with abundant melanin granules
● Melanocytes are scattered throughout the lesion
● No atypia
Basaloid cells form well-defined islands; numerous melanocytes are scattered throughout the lesion
Electron macroscopy description
● Composed of benign keratinocytes and dendritic melanocytes, incomplete transfer of pigment from melanocytes to keratinocytes, normal population of Langerhan’s cells
(J of Cutan Pathol 1978;5:127)
● Pigmented malignant hidroacanthoma
● Pigmented squamous cell carcinoma
● Pigmented basal cell carcinoma
End of Skin - Nonmelanocytic tumors > Benign nonmelanotic epidermal tumors / tumor-like lesions > Melanoacanthoma
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