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Skin - Nonmelanocytic tumors

Carcinoma (non-adnexal)

Merkel cell carcinoma - staging

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 15 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.


● Click here for staging Merkel cell carcinoma of eyelid

Primary tumor (T):
TX: Primary tumor cannot be assessed
T0: No evidence of primary tumor (e.g. nodal/metastatic presentation without associated primary)
Tis: In situ primary tumor
T1: Less than or equal to 2 cm maximum tumor dimension
T2: Greater than 2 cm but not more than 5 cm maximum tumor dimension
T3: Over 5 cm maximum tumor dimension
T4: Primary tumor invades bone, muscle, fascia or cartilage

Regional lymph nodes (N):
NX: Regional lymph nodes cannot be assessed
N0: No regional lymph node metastasis (negative nodes by clinical, pathologic, or both types of exam)
cN0: Nodes not clinically detectable (patient did not undergo pathologic node staging)
cN1: Nodes clinically detectable
pN0: Nodes negative by pathologic exam
pNx: Nodes not examined pathologically
N1: Metastasis in regional lymph node(s)
N1a: Micrometastasis (diagnosed after sentinel or elective lymphadenectomy)
N1b: Macrometastasis (defined as clinically detectable nodal metastases confirmed by therapeutic lymphadenectomy or needle biopsy)
N2: In transit metastasis (a tumor distinct from the primary lesion and located either between the primary lesion and the draining regional lymph nodes, or distal to the primary lesion

Distant metastasis (M):
Mx: Distant metastasis cannot be assessed
M0: No distant metastasis
M1: Metastasis beyond regional lymph nodes
M1a: Metastasis to skin, subcutaneous tissues or distant lymph nodes
M1b: Metastasis to lung
M1c: Metastasis to all other visceral sites

Stage grouping:
Stage 0: Tis N0 M0
Stage IA: T1 pN0 M0
Stage IB: T1 cN0 M0
Stage IIA: T2-3 pN0 M0
Stage IIB: T2-3 cN0 M0
Stage IIC: T4 N0 M0
Stage IIIA: Any T N1a M0
Stage IIIB: Any T N1b/N2 M0
Stage IV: M1 (Any T, Any N)

Additional references

J Am Acad Dermatol 2010;63:751

End of Skin - Nonmelanocytic tumors > Carcinoma (non-adnexal) > Merkel cell carcinoma - staging

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