Skin - Nonmelanocytic tumors
Metastatic carcinoma to skin
Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 15 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.
● Men: usually from lung (25%), colon, melanoma, kidney, upper aerodigestive tract
● Women: usually from breast (69%), lung, melanoma, kidney, ovary
● Metastasis is often close to site of primary
● 73 year old woman with adenocarcinoma of the colon (ISRN Surg 2011;2011:902971)
● 83 year old woman with bladder urothelial carcinoma (J Clin Pathol 2006;59:1331)
● 91 year old woman with breast adenocarcinoma metastatic to the eyelid (BMJ 2007;334:1228)
● Often multiple firm, nonulcerated nodules
● May be solitary
Various images of cutaneous metastases
Metastatic breast cancer is p63 negative (basal epidermis is p63+)
Metastatic bladder urothelial carcinoma
● p63 is negative in metastatic adenocarcinoma vs. positive in cutaneous adnexal tumors
(Mod Pathol 2005;18:137), although primary cutaneous adnexal tumors with apocrine or mucinous differentiation may be p63 negative (Mod Pathol 2010;23:713)
● Sweat gland tumor: may resemble metastatic renal cell carcinoma
● Dermatofibrosarcoma protuberans: may resemble metastatic signet ring carcinoma
● Merkel cell carcinoma: resembles neuroendocrine metastases
End of Skin - Nonmelanocytic tumors > Carcinoma (non-adnexal) > Metastatic carcinoma to skin
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