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Skin - Nonmelanocytic tumors

Adnexal tumors - eccrine sweat glands

Mucinous carcinoma

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 4 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Also called adenocystic carcinoma
● Scalp of elderly patients
● Caucasian > Black > Asian

Case reports
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● 50 year old woman with gluteal mass (Indian J Pathol Microbiol 2009;52:225)
● 58 year old Jamaican man with mass on left cheek (Dermatol Surg 2011;37:1192)

Gross description
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● Slow growing, solitary, asymptomatic, flesh colored nodule with a slightly translucent surface

Micro description
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● Resembles mammary colloid carcinoma with lakes of mucin containing small tumor cell clusters
● May also have an infiltrating ductal pattern

Micro images
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Gluteal mass

Positive stains
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● Primary skin tumors: 100% CK7+, 40% showed rare p63+ cells, 20% had focal CK5/6+

Differential diagnosis
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● Metastatic breast mucinous carcinoma: CK7+, 60% are p63+, otherwise negative (J Cutan Pathol 2010;37:411)
● Metastatic colonic mucinous carcinoma: CK20+

End of Skin - Nonmelanocytic tumors > Adnexal tumors - eccrine sweat glands > Mucinous carcinoma

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