Skin - Nonmelanocytic tumors
Adnexal tumors - eccrine sweat glands
Syringocystadenoma papilliferum

Author: Christopher Hale, M.D. (see Authors page)

Revised: 19 April 2017, last major update June 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Syringocystadenoma papilliferum [title]

Cite this page: Syringocystadenoma papilliferum. website. Accessed October 17th, 2018.
Definition / general
  • Also known as papillary syringadenoma
  • Warty tumor of scalp, neck and face that occurs at any age
  • Slow growing or a recent change in an apparent birthmark
  • 1/3 have adjacent nevus sebaceus, 10% have adjacent basal cell carcinoma
  • Eccrine syringofibroadenoma: with prominent fibrous stroma
  • Syringocystadenocarcinoma papilliferum: malignant counterpart
Clinical images

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Syringocystadenoma papilliferum

Microscopic (histologic) description
  • Glandular papillary proliferation connected to skin surface, dense plasma cell infiltrate
Microscopic (histologic) images

Images hosted on PathOut server:

Images contributed by Joel Pinczewski MD PhD, Australia


Syringocystadenoma Papilliferum: right - increased magnification

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Images hosted on Flickr:

Ulcerated scalp mass of 20 years duration, images courtesy of Dr. Okechukwu Okafor

Positive stains
  • Plasma cells are IgA+, IgG+