Skin - Nonmelanocytic tumors
Adnexal tumors - eccrine sweat glands
Syringocystadenoma papilliferum

Author: Christopher Hale, M.D. (see Authors page)

Revised: 6 October 2016, last major update June 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Syringocystadenoma papilliferum [title]

Cite this page: Syringocystadenoma papilliferum. website. Accessed October 22nd, 2016.
Definition / General
  • Also known as papillary syringadenoma
  • Warty tumor of scalp, neck and face that occurs at any age
  • Slow growing or a recent change in an apparent birthmark
  • 1/3 have adjacent nevus sebaceous, 10% have adjacent basal cell carcinoma
  • Eccrine syringofibroadenoma: with prominent fibrous stroma
  • Syringocystadenocarcinoma papilliferum: malignant counterpart
Clinical Images

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Syringocystadenoma papilliferum

Micro Description
  • Glandular papillary proliferation connected to skin surface, dense plasma cell infiltrate
Micro Images

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Ulcerated scalp mass of 20 years duration, images courtesy of Dr. Okechukwu Okafor

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Positive Stains
  • Plasma cells are IgA+, IgG+