Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Skin - Nonmelanocytic tumors

Lymphoma and related disorders

Peripheral T cell lymphoma


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 15 July 2012, last major update July 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● 50% of T cell lymphomas in Western countries
● A large and heterogenous group of lymphomas
● Median age 62 years
● Usually present with advanced stage disease with nodal involvement and variable marrow or extranodal involvement
● May have primarily skin involvement
● Aggressive - recurrences, progressive disease and death due to disease are common
● May resemble classic Hodgkin’s lymphoma due to Reed-Sternberg like cells, and occasional cases are CD15+ and CD30+ (Am J Surg Pathol 2003;27:1513)

Case reports
=========================================================================

● 3 year old with generalized intense itch (J Natl Med Assoc 2006;98:1992)
● 25 year old woman with previously treated peripheral T-cell lymphoma (PTCL) presenting with a recurrent lower eyelid lesion (Clin Ophthalmol 2009;3:527)

Clinical images
=========================================================================



Recurrent eyelid lesion

Micro images
=========================================================================



Recurrent eyelid lesion

Positive stains
=========================================================================

● CD45 (usually), T cell markers on all cells
● Occasionally CD15+ and CD30+ in both Reed-Sternberg like cells and background cells

Negative stains
=========================================================================

● Aberrant T cell expression (i.e. loss of some T cell markers)

Molecular
=========================================================================

● Clonal rearrangement
● Molecular signals help classify, including PTCL-unclassifiable and adult T-cell leukemia/lymphoma (Blood 2010;115:1026)

Differential diagnosis
=========================================================================

● Hodgkin’s lymphoma: background cells have normal morphology and normal T cell antigen expression; Reed-Sternberg like cells are negative for T cell antigens

End of Skin - Nonmelanocytic tumors > Lymphoma and related disorders > Peripheral T cell lymphoma


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).