Skin - Nonmelanocytic tumors
Vascular tumors
Pyogenic granuloma

Author: Christopher Hale, M.D. (see Authors page)

Revised: 7 October 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed search: pyogenic [title] granuloma skin

Cite this page: Pyogenic granuloma. website. Accessed December 12th, 2018.
Definition / general
  • Very common; rapidly growing polypoid red mass surrounded by thickened epidermis, often in finger or lips
  • Also called granuloma pyogenicum, lobular capillary hemangioma
  • May be associated with keratinous cyst
  • Benign, often regresses spontaneously
  • May be disseminated, occur within port wine stains, be in deep dermis / subcutis or be intravenous

  • Classic polypoid, dermal, subcutaneous, intravenous, eruptive, with multiple satellites
  • None or excision (may recur as multiple satellites)
Clinical images
Images hosted on PathOut server:

Pyogenic granuloma, c/o Dr. Mark R. Wick

Gross description
  • Fleshy cutaneous tumor
Microscopic (histologic) description
  • Lobular pattern of vascular proliferation with inflammation and edema resembling granulation tissue
  • Thin epidermis at top with variable ulceration
  • Acanthosis and hyperkeratosis at sides
  • Central branching vessel is called capillary or vascular lobule, with no / rare red blood cells, surrounded by endothelial cells
  • Variable mitotic activity
  • Deep lesions often lack edema and inflammation
Microscopic (histologic) images
Images hosted on PathOut server:

Pyogenic granuloma, courtesy of Dr. Mark R. Wick

Images hosted on other servers:

Low magnification