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Skin - Nonmelanocytic tumors

Adnexal tumors - eccrine sweat glands

Microcystic adnexal carcinoma

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 4 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.


● Also called sclerosing sweat gland carcinoma
● Slow growing nodule or plaque, usually on upper lip or face
● Difficult to achieve negative surgical margins, commonly recurs, metastases very rare
● Perineural invasion common

Case reports

● 57 year old Japanese man with facial plaque (Acta Derm Venereol 2012;92:109)

Gross description

● Slow-growing facial plaque

Gross images

An 81-year-old female with a large, hard-rubbery neoplasm involving ala nasi and right naso-genial sulcus

Micro description

● Cords and nests of bland keratinocytes, keratin cysts and ductal differentiation
● Dense collagenous stroma
● Is invasive, may extend into subcutis or perineural spaces
● Resembles syringoma
● Rarely is sebaceous differentiation

Micro images

At low power, there is an ill-defined lesion in the dermis;
There is solar elastosis in the superficial dermis;
Epidermis is uninvolved

The tumor consists of small infiltrating nests and cords; small ductule-like formations are noted
Single cells are also present; background stroma is sclerotic; perineural invasion is noted

Differential diagnosis

● Syringoma

End of Skin - Nonmelanocytic tumors > Adnexal tumors - eccrine sweat glands > Microcystic adnexal carcinoma

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