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Skin - Nonmelanocytic tumors

Adnexal tumors-sebaceous glands

Sebaceous carcinoma


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 14 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Rare
● Periocular vs. extraocular types
● Tumors of eyelids, caruncles and orbit are more aggressive than extraocular tumors
● May follow radiation therapy
● Also associated with Muir-Torre syndrome (multiple cutaneous tumors with sebaceous and hair follicle differentiation and multiple internal malignancies; tumors have cystic growth pattern, Histopathology 2010;56:133)
Poor prognostic factors: necrosis

Case reports
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● 32 year old caucasian woman with eyelid lesion (Diagn Pathol 2011;6:81)

Clinical images
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Sebaceous carcinoma presenting as a basal cell carcinoma of the left lower lid


Sebaceous carcinoma on the superior right eyelid superior

Micro description
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● Sebaceous differentiation, but also marked atypia, mitotic figures, invasion

Micro images
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Various images

Positive stains
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● Keratin, EMA, LeuM1, variable androgen receptors

Negative stains
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● CEA, S100

Differential diagnosis
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● Basal cell carcinoma with sebaceous differentiation
● Squamous cell carcinoma with hydropic change

End of Skin - Nonmelanocytic tumors > Adnexal tumors-sebaceous glands > Sebaceous carcinoma


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