Skin - Nonmelanocytic tumors
Adnexal tumors-sebaceous glands
Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 14 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.
● Periocular vs. extraocular types
● Tumors of eyelids, caruncles and orbit are more aggressive than extraocular tumors
● May follow radiation therapy
● Also associated with Muir-Torre syndrome (multiple cutaneous tumors with sebaceous and hair follicle differentiation and multiple internal malignancies; tumors have cystic growth pattern, Histopathology 2010;56:133)
● Poor prognostic factors: necrosis
● 32 year old caucasian woman with eyelid lesion
(Diagn Pathol 2011;6:81)
Sebaceous carcinoma presenting as a basal cell carcinoma of the left lower lid
Sebaceous carcinoma on the superior right eyelid superior
● Sebaceous differentiation, but also marked atypia, mitotic figures, invasion
● Keratin, EMA, LeuM1, variable androgen receptors
● CEA, S100
● Basal cell carcinoma with sebaceous differentiation
● Squamous cell carcinoma with hydropic change
End of Skin - Nonmelanocytic tumors > Adnexal tumors-sebaceous glands > Sebaceous carcinoma
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