Skin - Nonmelanocytic tumors
Other tumors of skin
Sinus histiocytosis with massive lymphadenopathy

Author: Christopher Hale, M.D. (see Authors page)

Revised: 6 October 2016, last major update September 2012

Copyright: (c) 2001-2016,, Inc.

PubMed search: sinus histiocytosis [title] massive lymphadenopathy, rosai-dorfman disease [title] skin

Cite this page: Sinus histiocytosis with massive lymphadenopathy. website. Accessed October 19th, 2018.
Definition / general
  • Very rare disorder, usually prominent cervical lymphadenopathy, but may involve skin
  • Also called Rosai-Dorfman disease
Case reports
Microscopic (histologic) description
  • Infiltration by sheets of large histiocytes with granular eosinophilic cytoplasm, large, round and vesicular nuclei, prominent nucleoli, and accompanied by plasma cells and lymphocytes, emperipolesis (histiocytes with intracytoplasmic lymphocytes)
Microscopic (histologic) images
Images hosted on other servers:

Various images

Positive stains
Negative stains