Skin nonmelanocytic tumor
Lymphoma and related disorders (see also Lymphoma chapter)
Sinus histiocytosis with massive lymphadenopathy

Topic Completed: 1 September 2012

Minor changes: 19 April 2019

Copyright: 2001-2019,, Inc.

PubMed search: sinus histiocytosis [title] massive lymphadenopathy, rosai-dorfman disease [title] skin

Christopher S. Hale, M.D.
Page views in 2019: 583
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Cite this page: Hale CS. Sinus histiocytosis with massive lymphadenopathy. website. Accessed August 6th, 2020.
Definition / general
  • Very rare disorder, usually prominent cervical lymphadenopathy, but may involve skin
  • Also called Rosai-Dorfman disease
Case reports
Microscopic (histologic) description
  • Infiltration by sheets of large histiocytes with granular eosinophilic cytoplasm, large, round and vesicular nuclei, prominent nucleoli, and accompanied by plasma cells and lymphocytes, emperipolesis (histiocytes with intracytoplasmic lymphocytes)
Microscopic (histologic) images
Images hosted on other servers:

Various images

Positive stains
Negative stains
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