Table of ContentsDefinition / general | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains
Cite this page: Sinus histiocytosis with massive lymphadenopathy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skintumornonmelanocyticsinushistiocytosis.html. Accessed July 18th, 2018.
Definition / general
- Very rare disorder, usually prominent cervical lymphadenopathy, but may involve skin
- Also called Rosai-Dorfman disease
Microscopic (histologic) description
- Infiltration by sheets of large histiocytes with granular eosinophilic cytoplasm, large, round and vesicular nuclei, prominent nucleoli, and accompanied by plasma cells and lymphocytes, emperipolesis (histiocytes with intracytoplasmic lymphocytes)