Skin tumor - Nonmelanocytic - Sinus histiocytosis with massive lymphadenopathy

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Skin - Nonmelanocytic tumors

Other tumors of skin

Sinus histiocytosis with massive lymphadenopathy

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 18 September 2012, last major update September 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Very rare disorder, usually prominent cervical lymphadenopathy, but may involve skin
● Also called Rosai-Dorfman disease

Case reports
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● 65 year old man with lip nodule (Dermatol Online J 2006;12:8)
● 82 year old woman treated with Acitretin (J Clin Aesthet Dermatol 2010;3:34)

Micro description
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● Infiltration by sheets of large histiocytes with granular eosinophilic cytoplasm, large, round and vesicular nuclei, prominent nucleoli, and accompanied by plasma cells and lymphocytes, emperipolesis (histiocytes with intracytoplasmic lymphocytes)

Micro images
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Various images

Positive stains
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● S100

Negative stains
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● CD1a

End of Skin - Nonmelanocytic tumors > Other tumors of skin > Sinus histiocytosis with massive lymphadenopathy

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