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Skin - Nonmelanocytic tumors

Adnexal tumors - eccrine sweat glands

Sweat gland carcinoma

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 4 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Uncommon
● Usually adults
● Difficult to diagnose
● May be life threatening

Low grade:
● Microcystic carcinoma, adenoid cystic carcinoma, mucinous carcinoma, extramammary Paget’s disease, mucoepidermoid carcinoma

Intermediate grade:
● Ductal adenocarcinoma, aggressive digital papillary adenocarcinoma, acrospirocarcinoma

High grade:
● Porocarcinoma, clear cell acrospirocarcinoma

Unknown grade:
● Signet ring cell carcinoma, papillary syringadenocarcinoma

● Also includes adenoid cystic carcinoma, apocrine carcinoma, malignant acrospiroma, malignant chondroid syringoma (malignant mixed tumor), malignant dermal cylindroma, malignant eccrine poroma (most common), malignant myoepithelioma, malignant syringoma (syringoid eccrine carcinoma), mucinous syringometaplasia
● Benign sweat gland tumors can also undergo malignant transformation to high grade carcinoma

Micro description
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● May resemble breast carcinoma, renal cell carcinoma, basal cell carcinoma

Positive stains
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● GCDFP-15, estrogen receptor, keratin, EMA, CEA

Negative stains
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● Actin

Differential diagnosis
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● Metastatic breast carcinoma
● Renal cell carcinoma

End of Skin - Nonmelanocytic tumors > Adnexal tumors - eccrine sweat glands > Sweat gland carcinoma

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